Adenine nucleotides regulate Ca2+ transport in brain mitochondria

Adenine nucleotides (ADP>ATP) greatly enhance Ca2+ uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca2+ down to cellular free Ca2+ levels, suggesting a role for mitochondria in modulating Ca2+ cycles in brain cells. Analysis o...

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Bibliographic Details
Published in:FEBS letters 1989-04, Vol.247 (2), p.483-486
Main Authors: Rottenberg, Hagai, Marbach, Miriam
Format: Article
Language:English
Subjects:
Adenine nucleotide
Adenosine Diphosphate - pharmacology
Adenosine Triphosphate - pharmacology
Animals
Atractyloside - pharmacology
Biological and medical sciences
Biological Transport - drug effects
Bongkrekic Acid - pharmacology
Brain - metabolism
Brain - ultrastructure
Ca2
Calcium - metabolism
Cell physiology
Egtazic Acid - pharmacology
Fundamental and applied biological sciences. Psychology
Membrane and intracellular transports
Mitochondria
Mitochondria - metabolism
Mitochondrial ADP, ATP Translocases - antagonists & inhibitors
Mitochondrial ADP, ATP Translocases - metabolism
Molecular and cellular biology
Rats
Spermine
Spermine - pharmacology
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Summary:Adenine nucleotides (ADP>ATP) greatly enhance Ca2+ uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca2+ down to cellular free Ca2+ levels, suggesting a role for mitochondria in modulating Ca2+ cycles in brain cells. Analysis of the effects of various inhibitors on Ca2+ uptake and efflux suggest that locking the ADP/ATP translocator in its M‐state stimulates electrogenic Ca2+ uptake and, to a lesser extent, inhibits Ca2+ efflux. It is suggested that this effect is due to a modulation of the surface charge on the M‐side which enhances Ca2+ dissociation from the carriers.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)81396-1