IS ATHEROSCLEROSIS EXCLUSIVELY A POSTPRANDIAL PHENOMENON?

SUMMARY 1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many ar...

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Bibliographic Details
Published in:Clinical and experimental pharmacology & physiology 1997-04, Vol.24 (3-4), p.288-293
Main Authors: Mamo, John CL, Yu, Kenneth CW, Elsegood, Caryn L., Smith, Darrin, Vine, Donna, Gennat, Hanni C., Voevodin, Melanie, Proctor, Spencer D.
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - etiology
Arteriosclerosis - metabolism
atherosclerosis
Biological Transport
chylomicrons
Chylomicrons - metabolism
Foam Cells - physiology
Humans
Lipoproteins, LDL - metabolism
low density lipoproteins
Postprandial Period
postprandial phenomenon
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Summary:SUMMARY 1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with various aspects of LDL metabolism. 2. Postprandial lipoproteins (i.e. chylomicrons transporting dietary fats) are also considered pro‐atherogenic; however, it is less clear whether their involvement in arterial cholesterol deposition is direct or follows modulation of LDL metabolism. 3. In order to provoke discussion, this article is presented in a manner that suggests atherosclerosis to be exclusively a postprandial phenomenon; that is, we have raised the possibility that LDL is non‐atherogenic.
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.1997.tb01822.x