Histopathological Impacts of Hepatitis Virus Infection in Hemodialysis Patients: Should Liver Biopsy Be Performed Before Renal Transplantation?

: To evaluate the histologic changes in the livers of renal transplant candidates who were infected with hepatitis viruses, we performed a percutaneous liver biopsy in each of 74 regular hemodialysis patients. Forty percent of them were seropositive for the antibody to hepatitis C virus (anti‐HCV) w...

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Bibliographic Details
Published in:Artificial organs 1997-05, Vol.21 (5), p.355-358
Main Authors: Özdoĝan, Mete, Özgür, Orhan, Gür, Gürden, Boyacioĝlu, Sedat, Özderin, Yasemin, Demirhan, Beyhan, Telatar, Hasan, Haberal, Mehmet
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy, Needle
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus - immunology
Hepacivirus - metabolism
Hepatitis B Antibodies - analysis
Hepatitis B Surface Antigens - analysis
Hepatitis B Surface Antigens - immunology
Hepatitis B virus - immunology
Hepatitis C - pathology
Hepatitis C - physiopathology
Hepatitis C Antibodies - analysis
Hepatitis viruses
Humans
Kidney Transplantation
Liver - pathology
Liver - virology
Liver Cirrhosis - physiopathology
Liver disease
Male
Middle Aged
Renal Dialysis - adverse effects
Renal transplantation
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Summary:: To evaluate the histologic changes in the livers of renal transplant candidates who were infected with hepatitis viruses, we performed a percutaneous liver biopsy in each of 74 regular hemodialysis patients. Forty percent of them were seropositive for the antibody to hepatitis C virus (anti‐HCV) whereas 29.7% had anti‐HCV and antibody to hepatitis B surface antigen (anti‐HBs) concomitantly. Seven (9.5%) were seropositive for only hepatitis B surface antigen HBsAg. Histopathological examination revealed that 30% of patients had chronic active hepatitis (CAH), 11% had chronic persistent hepatitis (CPH), and 3% displayed histopathological evidence of cirrhosis. Eleven of 22 patients with CAH were positive for only anti‐HCV, and 2 of 22 were positive for only HBsAg. One patient had HBsAg and anti‐HCV together, and 8 of 22 had anti‐HBs and anti‐HCV concomitantly. None of the anti‐HBs positive patients exhibited abnormal histopathological changes. We found no statistically significant difference in histopathological findings between the HBsAg positive and anti‐HCV positive patients. As 32 of 74 patients (43%) had some degree of chronic liver disease, we concluded that it is prudent to evaluate liver histology in HBsAg and anti‐HCV seropositive renal transplant candidates before transplantation.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.1997.tb00730.x