Attention deficit disorder symptoms and urine catecholamines

• Published in: Psychiatry research 1989-03, Vol.27 (3), p.241-251
• Main Authors: Rogeness, Graham A., Maas, James W., Javors, Martin A., Macedo, Carlos A., Fischer, Charles, Harris, William R.
• Format: Article
• Language: English
• Subjects: Attention deficit disorder; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - enzymology; Biological and medical sciences; catecholamines; Catecholamines - urine; Child; Child clinical studies; conduct disorder; Dopamine - urine; Dopamine beta-Hydroxylase - blood; dopamine-β-hydroxylase; Epinephrine - urine; Homovanillic Acid - urine; Humans; Hydroxyindoleacetic Acid - urine; Male; Medical sciences; Methoxyhydroxyphenylglycol - urine; norepinephrine; Norepinephrine - urine; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Vanilmandelic Acid - urine
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/0165-1781(89)90140-6

The symptoms of hyperactivity, impulsivity, and concentration deficits associated with attention deficit disorder (ADD) may be related, in part, to alterations in dopaminergic and noradrenergic functioning. In this study we correlate the above symptoms with 24-hour urinary catecholamines and their metabolites in emotionally disturbed boys divided into two groups based on their plasma dopamine-β-hydroxylase (DBH) activities and also divided into the following diagnostic groups: conduct disorder, undersocialized; conduct disorder, socialized; and subjects without conduct disorder. Boys in the low DBH group showed significant correlations between the ADD symptoms and the biochemical measures. The low DBH group may be more genetically homogeneous with regard to catecholamine function, making relationships between catecholamine function and behavior more visible. The group of boys with conduct disorder, socialized had higher 24-hour urinary norepinephrine and vanillylmandelic acid output. The relationship between monoamines and their metabolites appeared to differ among diagnostic groups.