Brain oxytocin receptor antagonism disinhibits sodium appetite in preweanling rats

Previous studies have shown that preweanling rats do not express an endogenous sodium appetite until postnatal day 12. The present studies tested the hypothesis that prior to 12 days of age sodium appetite, induced by either central administration of angiotensin II (AngII) or adrenalectomy, is inhib...

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Bibliographic Details
Published in:Regulatory peptides 1997-01, Vol.68 (2), p.119-124
Main Authors: Chow, S.Y, Sakai, R.R, Fluharty, S.J, Flanagan-Cato, L.M
Format: Article
Language:English
Subjects:
Adrenalectomy
Angiotensin II
Angiotensin II - pharmacology
Animals
Animals, Newborn
Appetite - drug effects
Appetite - physiology
Biological and medical sciences
Body Weight - drug effects
Brain - metabolism
Development
Electrolyte balance
Feeding Behavior - drug effects
Fundamental and applied biological sciences. Psychology
Ingestive behavior
Metabolisms and neurohumoral controls
Milk
Oxytocin - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Oxytocin - antagonists & inhibitors
Sodium - administration & dosage
Vasotocin - analogs & derivatives
Vasotocin - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Water and mineral metabolism. Osmoregulation. Acidobasic balance
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Summary:Previous studies have shown that preweanling rats do not express an endogenous sodium appetite until postnatal day 12. The present studies tested the hypothesis that prior to 12 days of age sodium appetite, induced by either central administration of angiotensin II (AngII) or adrenalectomy, is inhibited by endogenous oxytocin (OT). After 9- or 10-day old animals were given a central injection of either an OT receptor antagonist or vehicle, they were infused intraorally with 4% sodium chloride which the animals could either swallow or reject. Intake was measured as the increase from initial body weight. There was very little sodium consumption by vehicle-injected animals that received sham surgery or adrenalectomy; however, the OT receptor antagonist significantly elevated sodium consumption in adrenalectomized animals. The OT antagonist also potentiated sodium intake after AngII pretreatment. These results suggest that the neurochemical circuits necessary for the expression of sodium appetite are present and functional as early as postnatal day 9; however, until 12 days of age this behavior is suppressed by endogenous OT.
ISSN:0167-0115
1873-1686
DOI:10.1016/S0167-0115(96)02114-3