Prevention of neutrophil apoptosis by monosodium urate crystals

The effects of monosodium urate (MSU) crystals on apoptosis of cultured peripheral blood neutrophils were investigated. MSU crystals at low concentrations decreased the rate of spontaneous apoptosis of neutrophils in a dose- and time-dependent manner. The culture supernatant of MSU crystal stimulate...

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Bibliographic Details
Published in:Rheumatology international 1997-03, Vol.16 (6), p.231-235
Main Authors: AKAHOSHI, T, NAGAOKA, T, NAMAI, R, SEKIYAMA, N, KONDO, H
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Cells, Cultured
Crystals
Humans
Medical sciences
Metabolic diseases
Microscopy, Electron
Neutrophils - pathology
Neutrophils - ultrastructure
Other metabolic disorders
Purines and pyrimidines (gout, hyperuricemia...)
Uric Acid - pharmacology
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Summary:The effects of monosodium urate (MSU) crystals on apoptosis of cultured peripheral blood neutrophils were investigated. MSU crystals at low concentrations decreased the rate of spontaneous apoptosis of neutrophils in a dose- and time-dependent manner. The culture supernatant of MSU crystal stimulated neutrophils also promoted a delay in neutrophil apoptosis. MSU crystals at higher concentrations rapidly caused cell lysis. These findings indicated that MSU crystals are capable of amplifying the inflammatory responses of gouty arthritis by decreasing the rates of neutrophil apoptosis at lower concentrations and inducing cell lysis at higher concentrations.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF01375654