Atropine decreases drinking but not feeding and induces less hypothalamic acetylcholine release in diabetic rats

Drinking, feeding and hypothalamic extracellular acetylcholine (ACh) release was measured before and after the administration of several doses of atropine sulfate in streptozotocin (STZ)-diabetic and normal rats. Drinking but not feeding was dose-relatedly decreased by i.p. or intrahypothalamic inje...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1997-03, Vol.752 (1), p.184-188
Main Authors: Murzi, E., Rada, P., Puig de Parada, M., Parada, M.A., Valecillos, B., Tilac, C.A., Hernandez, L.
Format: Article
Language:English
Subjects:
Acetylcholine
Acetylcholine - metabolism
Animals
Atropine
Atropine - pharmacology
Diabetes mellitus
Diabetes Mellitus, Experimental - metabolism
Dose-Response Relationship, Drug
Drinking
Drinking - drug effects
Eating - drug effects
Hypothalamus - drug effects
Hypothalamus - metabolism
Injections
Injections, Intraperitoneal
Lateral hypothalamus
Male
Microdialysis
Muscarinic Antagonists - pharmacology
Rats
Rats, Wistar
Reference Values
Streptozotocin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drinking, feeding and hypothalamic extracellular acetylcholine (ACh) release was measured before and after the administration of several doses of atropine sulfate in streptozotocin (STZ)-diabetic and normal rats. Drinking but not feeding was dose-relatedly decreased by i.p. or intrahypothalamic injections of atropine in STZ-diabetic rats. Hypothalamic ACh release, as measured by microdialysis, increased less (dose-related) in diabetic than normal rats following an i.p. administration of atropine. Ach basal levels were the same in both groups. These results are discussed in terms of a hyperactive hypothalamic cholinergic (muscarinic) system involved in the diabetic polydipsia.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(96)01442-4