Candida tropicalis arthritis in a patient with acute myeloid leukemia successfully treated with fluconazole : Case report and review of the literature

The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. A literature review of C. tropicalis non-prosthetic arthritis is included. The isolate was susceptible to fluconazole (MIC 0.25...

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Bibliographic Details
Published in:Infection 1997-03, Vol.25 (2), p.109-111
Main Authors: WEERS-POTHOFF, G, HAVERMANS, J. F, KAMPHUIS, J, SINNIGE, H. A. M, MEIS, J. F. G. M
Format: Article
Language:English
Subjects:
Aged
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Arthritis, Infectious - complications
Arthritis, Infectious - drug therapy
Biological and medical sciences
Candidiasis - complications
Candidiasis - drug therapy
Child
Female
Fluconazole - administration & dosage
Fluconazole - therapeutic use
Human mycoses
Humans
Infant, Newborn
Infectious diseases
Knee - microbiology
Leukemia, Myeloid, Acute - complications
Male
Medical sciences
Middle Aged
Mycoses
Mycoses of the osteoarticular system
Shoulder - microbiology
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Summary:The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. A literature review of C. tropicalis non-prosthetic arthritis is included. The isolate was susceptible to fluconazole (MIC 0.25 mg/l). She was treated with fluconazole (400 mg orally) and frequent relieving synovial aspirations. After 1 month of antifungal therapy the synovial fluid became culture negative. Fluconazole concentration in the synovial fluid and serum were 20 mg/l and 19.4 mg/l, respectively. The patient was treated for a total of 7 months and made a full recovery. This is the first report of the successful use of fluconazole in the treatment of septic arthritis due to C. tropicalis.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF02113588