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The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group

Seminiferous tubules adjacent to germ cell tumors (GCT) in prepubertal boys frequently contain increased germ cells with abundant, clear cytoplasm. These cells are placental alkaline phosphatase (PLAP) negative and are usually not considered to represent intratubular germ cell neoplasia (ITGCN). A r...

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Published in:Human pathology 1997-04, Vol.28 (4), p.404-409
Main Authors: Hawkins, Edith, Heifetz, Stephen A, Giller, Roger, Cushing, Barbara
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Heifetz, Stephen A
Giller, Roger
Cushing, Barbara
description Seminiferous tubules adjacent to germ cell tumors (GCT) in prepubertal boys frequently contain increased germ cells with abundant, clear cytoplasm. These cells are placental alkaline phosphatase (PLAP) negative and are usually not considered to represent intratubular germ cell neoplasia (ITGCN). A recent case report found p53 and proliferating cell nuclear antigen (PCNA) positivity in such cells and equated these PLAP-negative cells with ITGCN. Because the proto-oncogene c-kit is also a marker of ITGCN, immunohistochemical tests for c- kit and PLAP were performed on 28 testes adjacent to prepubertal GCT in children aged 2 to 45 months. Additional slides from testes not associated with GCT from 18 preterm infants and children ages 19 weeks to 7 years were also tested. An adult testis with seminoma and ITGCN served as a positive control. PCNA, PLAP, and p53 were tested on available slides. No intratubular germ cells adjacent to GCT in prepubertal children were positive for PLAP or c- kit; five of seven were positive for PCNA; p53 was present in the two examined. These results indicate that germ cells adjacent to infantile GCT are proliferative but not neoplastic and offer additional evidence that intratubular germ cells and GCT in prepubertal boys are different from those of adolescents and adults.
doi_str_mv 10.1016/S0046-8177(97)90027-7
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Obstetrics ; Humans ; Immunohistochemistry ; Infant ; intratubular germ cell neoplasia ; Male ; Male genital diseases ; Medical sciences ; Neoplasms, Germ Cell and Embryonal - chemistry ; Neoplasms, Germ Cell and Embryonal - pathology ; prepubertal testis ; Proliferating Cell Nuclear Antigen - analysis ; Proto-Oncogene Proteins c-kit - analysis ; Seminiferous Tubules - chemistry ; Seminiferous Tubules - pathology ; Seminoma - pathology ; Testis - chemistry ; Testis - pathology ; Tumor Suppressor Protein p53 - analysis ; Tumors</subject><ispartof>Human pathology, 1997-04, Vol.28 (4), p.404-409</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-75bf49995527b4b060773463e6b10ff57081b925c058a2423f0cc5791f0b144c3</citedby><cites>FETCH-LOGICAL-c441t-75bf49995527b4b060773463e6b10ff57081b925c058a2423f0cc5791f0b144c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2675695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9104938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawkins, Edith</creatorcontrib><creatorcontrib>Heifetz, Stephen A</creatorcontrib><creatorcontrib>Giller, Roger</creatorcontrib><creatorcontrib>Cushing, Barbara</creatorcontrib><title>The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Seminiferous tubules adjacent to germ cell tumors (GCT) in prepubertal boys frequently contain increased germ cells with abundant, clear cytoplasm. These cells are placental alkaline phosphatase (PLAP) negative and are usually not considered to represent intratubular germ cell neoplasia (ITGCN). A recent case report found p53 and proliferating cell nuclear antigen (PCNA) positivity in such cells and equated these PLAP-negative cells with ITGCN. Because the proto-oncogene c-kit is also a marker of ITGCN, immunohistochemical tests for c- kit and PLAP were performed on 28 testes adjacent to prepubertal GCT in children aged 2 to 45 months. Additional slides from testes not associated with GCT from 18 preterm infants and children ages 19 weeks to 7 years were also tested. An adult testis with seminoma and ITGCN served as a positive control. PCNA, PLAP, and p53 were tested on available slides. No intratubular germ cells adjacent to GCT in prepubertal children were positive for PLAP or c- kit; five of seven were positive for PCNA; p53 was present in the two examined. These results indicate that germ cells adjacent to infantile GCT are proliferative but not neoplastic and offer additional evidence that intratubular germ cells and GCT in prepubertal boys are different from those of adolescents and adults.</description><subject>Adult</subject><subject>Alkaline Phosphatase - analysis</subject><subject>Biological and medical sciences</subject><subject>c-kit</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Fetus</subject><subject>germ cells</subject><subject>Germ Cells - chemistry</subject><subject>Germ Cells - pathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>intratubular germ cell neoplasia</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Neoplasms, Germ Cell and Embryonal - chemistry</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>prepubertal testis</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Proto-Oncogene Proteins c-kit - analysis</subject><subject>Seminiferous Tubules - chemistry</subject><subject>Seminiferous Tubules - pathology</subject><subject>Seminoma - pathology</subject><subject>Testis - chemistry</subject><subject>Testis - pathology</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkc9q3DAQxkVpSTdpHyGgQ2mTg1vJliwrlxJC_wQCPTQ9C0ke76poLVeSC3mnPmTkXbPXgkBo5jczmu9D6JKSj5TQ9tNPQlhbdVSIKymuJSG1qMQLtKG8qauukfVLtDkhr9F5Sr8JoZQzfobOJCVMNt0G_XvcAZ4iTLOBmLXHGVJ2CV-V2KiXgB57PIWUD6_rG3yfE47gdXZhTDs34RywG3PUeTaz1xFvIe6xBe_xCGHyOjl9g2-xDXvjRijNoHc6R2dxGG3wYfuEtzHM02GS3Tnfl9EfErZ6tBBxynO_Em_Qq0H7BG_X-wL9-vrl8e579fDj2_3d7UNlGaO5EtwMTErJeS0MM6QlQjSsbaA1lAwDF6SjRtbcEt7pmtXNQKzlQtKBGMqYbS7Q-2PfKYY_cxFE7V1aNtJlozkp0cm2yEwLyI-gjSGlCIOaotvr-KQoUYtL6uCSWixQspzFJSVK3eU6YDZ76E9Vqy0l_27N62S1H2KRwqUTVreCt5IX7PMRgyLGXwdRJeugqNa7CDarPrj_fOQZsxWxFw</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Hawkins, Edith</creator><creator>Heifetz, Stephen A</creator><creator>Giller, Roger</creator><creator>Cushing, Barbara</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group</title><author>Hawkins, Edith ; Heifetz, Stephen A ; Giller, Roger ; Cushing, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-75bf49995527b4b060773463e6b10ff57081b925c058a2423f0cc5791f0b144c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - analysis</topic><topic>Biological and medical sciences</topic><topic>c-kit</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Fetus</topic><topic>germ cells</topic><topic>Germ Cells - chemistry</topic><topic>Germ Cells - pathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>intratubular germ cell neoplasia</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Neoplasms, Germ Cell and Embryonal - chemistry</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>prepubertal testis</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Proto-Oncogene Proteins c-kit - analysis</topic><topic>Seminiferous Tubules - chemistry</topic><topic>Seminiferous Tubules - pathology</topic><topic>Seminoma - pathology</topic><topic>Testis - chemistry</topic><topic>Testis - pathology</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawkins, Edith</creatorcontrib><creatorcontrib>Heifetz, Stephen A</creatorcontrib><creatorcontrib>Giller, Roger</creatorcontrib><creatorcontrib>Cushing, Barbara</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawkins, Edith</au><au>Heifetz, Stephen A</au><au>Giller, Roger</au><au>Cushing, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>28</volume><issue>4</issue><spage>404</spage><epage>409</epage><pages>404-409</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Seminiferous tubules adjacent to germ cell tumors (GCT) in prepubertal boys frequently contain increased germ cells with abundant, clear cytoplasm. These cells are placental alkaline phosphatase (PLAP) negative and are usually not considered to represent intratubular germ cell neoplasia (ITGCN). A recent case report found p53 and proliferating cell nuclear antigen (PCNA) positivity in such cells and equated these PLAP-negative cells with ITGCN. Because the proto-oncogene c-kit is also a marker of ITGCN, immunohistochemical tests for c- kit and PLAP were performed on 28 testes adjacent to prepubertal GCT in children aged 2 to 45 months. Additional slides from testes not associated with GCT from 18 preterm infants and children ages 19 weeks to 7 years were also tested. An adult testis with seminoma and ITGCN served as a positive control. PCNA, PLAP, and p53 were tested on available slides. No intratubular germ cells adjacent to GCT in prepubertal children were positive for PLAP or c- kit; five of seven were positive for PCNA; p53 was present in the two examined. 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identifier ISSN: 0046-8177
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subjects Adult
Alkaline Phosphatase - analysis
Biological and medical sciences
c-kit
Child
Child, Preschool
Fetus
germ cells
Germ Cells - chemistry
Germ Cells - pathology
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Infant
intratubular germ cell neoplasia
Male
Male genital diseases
Medical sciences
Neoplasms, Germ Cell and Embryonal - chemistry
Neoplasms, Germ Cell and Embryonal - pathology
prepubertal testis
Proliferating Cell Nuclear Antigen - analysis
Proto-Oncogene Proteins c-kit - analysis
Seminiferous Tubules - chemistry
Seminiferous Tubules - pathology
Seminoma - pathology
Testis - chemistry
Testis - pathology
Tumor Suppressor Protein p53 - analysis
Tumors
title The prepubertal testis (prenatal and postnatal): Its relationship to intratubular germ cell neoplasia: A combined pediatric oncology group and children's cancer study group
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