Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy

Previous studies have shown that the sera of many patients with dilated cardiomyopathy (DCM) are positive for several antibodies directed against cardiac antigens. Anti-beta1-adrenergic receptor antibodies occur in 70% to 90% of DCM patients. These antibodies are extractable by immunoadsorption (IA)...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-04, Vol.95 (8), p.1994-1997
Main Authors: DÖRFFEL, W. V, FELIX, S. B, WALLUKAT, G, BREHME, S, BESTVATER, K, HOFMANN, T, KLEBER, F. X, BAUMANN, G, REINKE, P
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - physiopathology
Biological and medical sciences
Cardiac Catheterization
Cardiology. Vascular system
Cardiomyopathy, Dilated - complications
Cardiomyopathy, Dilated - drug therapy
Cardiomyopathy, Dilated - immunology
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Dilated - therapy
Combined Modality Therapy
Dyspnea - etiology
Dyspnea - therapy
Extracorporeal Circulation
Female
Heart
Hemodynamics
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunosorbent Techniques
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Receptors, Adrenergic, beta-1 - immunology
Stroke Volume
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have shown that the sera of many patients with dilated cardiomyopathy (DCM) are positive for several antibodies directed against cardiac antigens. Anti-beta1-adrenergic receptor antibodies occur in 70% to 90% of DCM patients. These antibodies are extractable by immunoadsorption (IA). In an investigation of the functional significance of antibodies for hemodynamics, IA was performed throughout 5 consecutive days on nine patients with severe DCM who were on stable drug therapy. Immunoglobulins were eliminated in nine patients with severe DCM (mean age, 43.5 years; range, 25 to 58 years; left ventricular ejection fraction,
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.95.8.1994