Immunological method for prediction of progress in neurological deficit in patients with intracranial aneurysm rupture

Skin tests of nonspecific antigens (immunoskin test Sevac) were performed on patients suffering from intracranial aneurysms, scheduled for surgical clipping. It was found that high antibody titre correlated well with the severity and progress of neurological deficit developing after surgery. This de...

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Bibliographic Details
Published in:Acta neurochirurgica 1989-01, Vol.97 (1-2), p.67-70
Main Authors: RYBA, M, PASTUSZKO, M, IWANSKA, K, KOZIARSKI, A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Humans
Immunity, Cellular
Intracranial Aneurysm - complications
Intracranial Aneurysm - immunology
Ischemic Attack, Transient - etiology
Ischemic Attack, Transient - immunology
Male
Medical sciences
Middle Aged
Neurology
Prognosis
Rupture, Spontaneous
Skin Tests - methods
Subarachnoid Hemorrhage - etiology
Subarachnoid Hemorrhage - immunology
Vascular diseases and vascular malformations of the nervous system
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Summary:Skin tests of nonspecific antigens (immunoskin test Sevac) were performed on patients suffering from intracranial aneurysms, scheduled for surgical clipping. It was found that high antibody titre correlated well with the severity and progress of neurological deficit developing after surgery. This deficit was absent in patients who exhibited low antibody titre in response to the skin test before surgery. These results indicate that the immunological processes may play a role in the development of neurological deficit after neurosurgical procedures. Thus the skin test employed may have prognostic value in predicting neurological deficit following intracranial aneurysm surgery.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01577742