Deletion polymorphism in the angiotensin-converting enzyme gene is not associated with hypertension in a Gulf Arab population

We have studied an insertion/deletion dimorphism in the human angiotensin‐converting enzyme gene amongst UAE nationals from the Abu Dhabi Emirate. Our findings show lack of association between the I/D allele marker system and clinical diagnosis of essential hypertension, suggesting that variations o...

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Bibliographic Details
Published in:Clinical genetics 1997-03, Vol.51 (3), p.211-213
Main Authors: Frossard, P. M., Obineche, E. N., Elshahat, Y. I., Lestringant, G. G.
Format: Article
Language:English
Subjects:
Alleles
angiotensin
Arterial hypertension. Arterial hypotension
association study
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
converting enzyme gene
essential hypertension
Female
Gene Deletion
Genetic Markers
Humans
Hypertension - ethnology
Hypertension - genetics
I/D polymorphism-United Arab Emirates
Male
Medical sciences
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Analysis, DNA
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Summary:We have studied an insertion/deletion dimorphism in the human angiotensin‐converting enzyme gene amongst UAE nationals from the Abu Dhabi Emirate. Our findings show lack of association between the I/D allele marker system and clinical diagnosis of essential hypertension, suggesting that variations of the angiotensin‐converting enzyme gene do not play a major role in the determination of elevated blood pressure in this Arab population. This agrees with results reported on other ethnic groups.
ISSN:0009-9163
1399-0004
DOI:10.1111/j.1399-0004.1997.tb02455.x