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Dietary and hypothalamic changes in delta 4-androstenedione-treated Zucker rats
Dehydroepiandrosterone (DHEA) has been shown to alter hypothalamic monoamines and reduce energy intake (EI) in Zucker rats (ZRs). We hypothesized that a metabolite of DHEA, delta 4-Androstenedione (delta 4), may mediate these effects. Male lean and obese ZRs (LZR, OZR) were fed control chow (CC) for...
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Published in: | Physiology & behavior 1997-04, Vol.61 (4), p.619-626 |
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description | Dehydroepiandrosterone (DHEA) has been shown to alter hypothalamic monoamines and reduce energy intake (EI) in Zucker rats (ZRs). We hypothesized that a metabolite of DHEA, delta 4-Androstenedione (delta 4), may mediate these effects. Male lean and obese ZRs (LZR, OZR) were fed control chow (CC) for 7 days, during which basal EI was recorded, various concentrations of delta 4 for 7 days, during which 0.6 and 0.3% delta 4 reduced EI significantly, and CC for 7 days, which resulted in a return of EI to basal levels. After delta 4 administration, neurotransmitter contents of various hypothalamic areas were determined. Serotonin (5-HT) has been shown to be correlated with feeding inhibition, and we have shown DHEA to increase lateral hypothalamic 5-HT synthesis; however, after 1 day and 7 days of delta 4, the OZR exhibited an increased metabolism, not synthesis, of 5-HT in the lateral and paraventricular hypothalamus, respectively, delta 4 was compared to DHEA in a macronutrient self-selection study with female OZRs. One group was injected intraperitoneally (IP) with sesame oil (control), another with DHEA (100 mg/kg), and another with delta 4 (100 mg/kg). Previous studies have shown that DHEA decreases both EI and % calories from fat. In this study, delta 4 decreased % calories from fat, but did not decrease total EI. Contrary to DHEA's effect of reducing serum insulin through 28 days of treatment, delta 4 in chow reduced insulin only acutely (1 day). We conclude, based on these differences, that DHEA has unique effects not mediated by its metabolite, delta 4-Androstenedione. |
doi_str_mv | 10.1016/S0031-9384(96)00514-8 |
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One group was injected intraperitoneally (IP) with sesame oil (control), another with DHEA (100 mg/kg), and another with delta 4 (100 mg/kg). Previous studies have shown that DHEA decreases both EI and % calories from fat. In this study, delta 4 decreased % calories from fat, but did not decrease total EI. Contrary to DHEA's effect of reducing serum insulin through 28 days of treatment, delta 4 in chow reduced insulin only acutely (1 day). We conclude, based on these differences, that DHEA has unique effects not mediated by its metabolite, delta 4-Androstenedione.</description><identifier>ISSN: 0031-9384</identifier><identifier>DOI: 10.1016/S0031-9384(96)00514-8</identifier><identifier>PMID: 9108584</identifier><language>eng</language><publisher>United States</publisher><subject>Androstenedione - pharmacology ; Animals ; Body Weight - drug effects ; Eating - drug effects ; Energy Intake - drug effects ; Female ; Hypothalamus - drug effects ; Male ; Rats ; Rats, Zucker</subject><ispartof>Physiology & behavior, 1997-04, Vol.61 (4), p.619-626</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-80211eca9eddd7b4067c2fbe55e710dd6240d9aa83f9d8f4ce79cfa7563d6fce3</citedby><cites>FETCH-LOGICAL-c267t-80211eca9eddd7b4067c2fbe55e710dd6240d9aa83f9d8f4ce79cfa7563d6fce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9108584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hargrave, K R</creatorcontrib><creatorcontrib>Wright, B E</creatorcontrib><creatorcontrib>Svec, F</creatorcontrib><creatorcontrib>Porter, J R</creatorcontrib><title>Dietary and hypothalamic changes in delta 4-androstenedione-treated Zucker rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Dehydroepiandrosterone (DHEA) has been shown to alter hypothalamic monoamines and reduce energy intake (EI) in Zucker rats (ZRs). We hypothesized that a metabolite of DHEA, delta 4-Androstenedione (delta 4), may mediate these effects. Male lean and obese ZRs (LZR, OZR) were fed control chow (CC) for 7 days, during which basal EI was recorded, various concentrations of delta 4 for 7 days, during which 0.6 and 0.3% delta 4 reduced EI significantly, and CC for 7 days, which resulted in a return of EI to basal levels. After delta 4 administration, neurotransmitter contents of various hypothalamic areas were determined. Serotonin (5-HT) has been shown to be correlated with feeding inhibition, and we have shown DHEA to increase lateral hypothalamic 5-HT synthesis; however, after 1 day and 7 days of delta 4, the OZR exhibited an increased metabolism, not synthesis, of 5-HT in the lateral and paraventricular hypothalamus, respectively, delta 4 was compared to DHEA in a macronutrient self-selection study with female OZRs. One group was injected intraperitoneally (IP) with sesame oil (control), another with DHEA (100 mg/kg), and another with delta 4 (100 mg/kg). Previous studies have shown that DHEA decreases both EI and % calories from fat. In this study, delta 4 decreased % calories from fat, but did not decrease total EI. Contrary to DHEA's effect of reducing serum insulin through 28 days of treatment, delta 4 in chow reduced insulin only acutely (1 day). We conclude, based on these differences, that DHEA has unique effects not mediated by its metabolite, delta 4-Androstenedione.</description><subject>Androstenedione - pharmacology</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Eating - drug effects</subject><subject>Energy Intake - drug effects</subject><subject>Female</subject><subject>Hypothalamus - drug effects</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Zucker</subject><issn>0031-9384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkLlOAzEQhl2AQgg8QiRXCIoFe-31UaJwSpFSAA2N5dizZGGPYHuLvD2bQ2mZZqTR989oPoSmlNxSQsXdGyGMZpopfq3FDSEF5Zk6QePj-Aydx_hNhmKcjdBIU6IKxcdo8VBBsmGDbevxarPu0srWtqkcdivbfkHEVYs91Mling1M6GKCFnzVtZClADaBx5-9-4GAg03xAp2Wto5weegT9PH0-D57yeaL59fZ_TxzuZApUySnFJzV4L2XS06EdHm5hKIASYn3IufEa2sVK7VXJXcgtSutLATzonTAJuhqv3cdut8eYjJNFR3UtW2h66ORSgvFC_IvSAXnUnIxgMUedMOPMUBp1qFqBjWGErO1bHaWzVan0cLsLBs15KaHA_2yAX9MHRSzP-fwe1U</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Hargrave, K R</creator><creator>Wright, B E</creator><creator>Svec, F</creator><creator>Porter, J R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>199704</creationdate><title>Dietary and hypothalamic changes in delta 4-androstenedione-treated Zucker rats</title><author>Hargrave, K R ; Wright, B E ; Svec, F ; Porter, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-80211eca9eddd7b4067c2fbe55e710dd6240d9aa83f9d8f4ce79cfa7563d6fce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Androstenedione - pharmacology</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Eating - drug effects</topic><topic>Energy Intake - drug effects</topic><topic>Female</topic><topic>Hypothalamus - drug effects</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Zucker</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hargrave, K R</creatorcontrib><creatorcontrib>Wright, B E</creatorcontrib><creatorcontrib>Svec, F</creatorcontrib><creatorcontrib>Porter, J R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hargrave, K R</au><au>Wright, B E</au><au>Svec, F</au><au>Porter, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary and hypothalamic changes in delta 4-androstenedione-treated Zucker rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1997-04</date><risdate>1997</risdate><volume>61</volume><issue>4</issue><spage>619</spage><epage>626</epage><pages>619-626</pages><issn>0031-9384</issn><abstract>Dehydroepiandrosterone (DHEA) has been shown to alter hypothalamic monoamines and reduce energy intake (EI) in Zucker rats (ZRs). We hypothesized that a metabolite of DHEA, delta 4-Androstenedione (delta 4), may mediate these effects. Male lean and obese ZRs (LZR, OZR) were fed control chow (CC) for 7 days, during which basal EI was recorded, various concentrations of delta 4 for 7 days, during which 0.6 and 0.3% delta 4 reduced EI significantly, and CC for 7 days, which resulted in a return of EI to basal levels. After delta 4 administration, neurotransmitter contents of various hypothalamic areas were determined. Serotonin (5-HT) has been shown to be correlated with feeding inhibition, and we have shown DHEA to increase lateral hypothalamic 5-HT synthesis; however, after 1 day and 7 days of delta 4, the OZR exhibited an increased metabolism, not synthesis, of 5-HT in the lateral and paraventricular hypothalamus, respectively, delta 4 was compared to DHEA in a macronutrient self-selection study with female OZRs. One group was injected intraperitoneally (IP) with sesame oil (control), another with DHEA (100 mg/kg), and another with delta 4 (100 mg/kg). Previous studies have shown that DHEA decreases both EI and % calories from fat. In this study, delta 4 decreased % calories from fat, but did not decrease total EI. Contrary to DHEA's effect of reducing serum insulin through 28 days of treatment, delta 4 in chow reduced insulin only acutely (1 day). We conclude, based on these differences, that DHEA has unique effects not mediated by its metabolite, delta 4-Androstenedione.</abstract><cop>United States</cop><pmid>9108584</pmid><doi>10.1016/S0031-9384(96)00514-8</doi><tpages>8</tpages></addata></record> |
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subjects | Androstenedione - pharmacology Animals Body Weight - drug effects Eating - drug effects Energy Intake - drug effects Female Hypothalamus - drug effects Male Rats Rats, Zucker |
title | Dietary and hypothalamic changes in delta 4-androstenedione-treated Zucker rats |
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