Recombinant Adenovirus: A Gene Transfer Vector for Study and Treatment of CNS Diseases

Gene transfer to the CNS with recombinant adenoviral vectors is a relatively recent event. In initial reports it was clearly demonstrated that adenoviral vectors can transfer genetic material to multiple cell types within the CNS. The relative ease in generating recombinant adenovirus (Ad) led to fe...

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Bibliographic Details
Published in:Experimental neurology 1997-03, Vol.144 (1), p.125-130
Main Authors: Davidson, Beverly L., Bohn, Martha C.
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Animals
Biological and medical sciences
Biotechnology
Central Nervous System Diseases - physiopathology
Central Nervous System Diseases - therapy
Fundamental and applied biological sciences. Psychology
Gene therapy
Gene Transfer Techniques
Genetic Vectors
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Recombination, Genetic
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Summary:Gene transfer to the CNS with recombinant adenoviral vectors is a relatively recent event. In initial reports it was clearly demonstrated that adenoviral vectors can transfer genetic material to multiple cell types within the CNS. The relative ease in generating recombinant adenovirus (Ad) led to feasibility studies in the CNS with application to animal models of inherited disease, neurodegenerative diseases (e.g., Parkinson's and amyotrophic lateral sclerosis), and cerebrovascular disease. In combination with Ad gene transfer to peripheral tissues, these experiments have identified specific limitations and directed further research to improve vector design, formulation, and delivery.
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.1996.6398