Infantile-onset multisystem inflammatory disease: A differential diagnosis of systemic juvenile rheumatoid arthritis

We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and ra...

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Bibliographic Details
Published in:The Journal of pediatrics 1997-04, Vol.130 (4), p.551-556
Main Authors: De Cunto, Carmen L., Liberatore, Diana I., San Román, José L., Goldberg, Julio C., Morandi, Ana A., Feldman, Guillermina
Format: Article
Language:English
Subjects:
Adolescent
Arthritis, Juvenile - diagnosis
Biological and medical sciences
Central Nervous System Diseases - complications
Child
Child, Preschool
Diagnosis, Differential
Diseases of the osteoarticular system
Female
Humans
Inflammation
Inflammatory joint diseases
Joint Diseases - complications
Joint Diseases - diagnosis
Medical sciences
Skin Diseases - complications
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Summary:We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and radiologic findings allowed us to include these children in a very peculiar syndrome described as infantile-onset multisystemic inflammatory disease. A chondrosarcoma developed in one of our patients. (J Pediatr 1997; 130:551-6)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(97)70238-5