Bone Morphogenesis and Modeling: Soluble Signals Sculpt Osteosomes in the Solid State

How is the bone modeled in the embryo and remodeled in the adult? This question is addressed by an exciting report in this issue of Cell by Simonet et al. describing a novel secreted member of the TNF receptor superfamily increasing bone density and is the focus of this minireview.

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Bibliographic Details
Published in:Cell 1997-04, Vol.89 (2), p.159-161
Main Author: Reddi, A.H.
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - embryology
Bone Density - physiology
Bone Remodeling - physiology
Humans
Morphogenesis
Rats
Receptors, Tumor Necrosis Factor - physiology
Signal Transduction
Space life sciences
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Description
Summary:How is the bone modeled in the embryo and remodeled in the adult? This question is addressed by an exciting report in this issue of Cell by Simonet et al. describing a novel secreted member of the TNF receptor superfamily increasing bone density and is the focus of this minireview.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80193-2