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Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994
Background The efficacy of cisplatinum combined chemotherapy modalities was investigated in a variety of trials for patients with advanced seminoma. Results regarding remission rates and survival are encouraging. Methods Between December 1981 and January 1994, 13 patients with either relapsed (follo...
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| Published in: | Journal of surgical oncology 1997-04, Vol.64 (4), p.331-335 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4625-ec316ef098f102225066555c74a92fb655cf345f4a13d1f7494d996cf9e594943 |
| container_end_page | 335 |
| container_issue | 4 |
| container_start_page | 331 |
| container_title | Journal of surgical oncology |
| container_volume | 64 |
| creator | Stein, Moshe E. Kuten, Abraham Drumea, Keren Moshkowitz, Boaz Nativ, Ofer Munichor, Mariane Haim, Nissim |
| description | Background
The efficacy of cisplatinum combined chemotherapy modalities was investigated in a variety of trials for patients with advanced seminoma. Results regarding remission rates and survival are encouraging.
Methods
Between December 1981 and January 1994, 13 patients with either relapsed (followng radiotherapy failure) or primarily advanced seminoma were treated with cisplatin‐based chemotherapy at the Northern Israel Oncology Center.
Results
Eleven (84%) patients achieved complete clearance of all sites of disease. One patient demonstrated clinically and radiographically remarkable shrinkage of an abdominal mass, and laparotomy revealed fibrotic/necrotic tissue without viable tumor cells. After a mean follow‐up of 58 months (range 4–168), 12 patients (92%) are alive and well without evidence of malignancy. One patient, in whom a 2‐cm abdominal mass is stable radiographically, is under observation with no sign of tumor activity. Side effects were tolerable; no patient developed chemotherapy‐induced sepsis. One patient developed spontaneous pneumothorax a few days after completion of his first chemotherapy cycle, which resolved with treatment.
Conclusions
Our results confirm the efficacy and safety of cisplatin‐based chemotherapy in the treatment of advanced seminoma, even in pre‐irradiated patients. J. Surg. Oncol. 64:331–335, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9098(199704)64:4<331::AID-JSO15>3.0.CO;2-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78971630</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78971630</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4625-ec316ef098f102225066555c74a92fb655cf345f4a13d1f7494d996cf9e594943</originalsourceid><addsrcrecordid>eNqFkUtvEzEUhUcIVELhJyB5gaBdTPB74tAiVUNpB4VOpfJYXjmOTQfmEewJNP8eh4lmA4KV7XuPj87RlySnBE8JxvTl0U2RF8cEK5kqrGZHRKkM82PJ5_yEMTKfnxVv0nc3JRGv2RRP8_IVTcW9ZDL-uJ9Mog9Neabww-RRCF8xxkpJfpAcKMIpUXSSdHkV1rXuqzZd6mBXyNzaputvrdfrLapapFc_dGviItimartGz9H53dr6ysYp6hyKWnTV-d2XFhXBa1ujsjVd3X3Zoty2vfVzRNSMpLEBf5w8cLoO9sn-PEw-vj3_kF-mi_KiyM8WqeGSitQaRqR1sYUjsQMVWEohhMm4VtQt4904xoXjmrAVcRlXfBWrGaesUPHBDpPng-_ad983NvTQVMHYutat7TYBspnKiGQ4Cl_8Wyi4kJwzycaoxncheOtg7atG-y0QDDtkADtksAMAOwAwIAPJgUNEBhCRwW9kwABDXgIFEX2f7hNslo1dja57RnH_bL_Xweja-cijCqOMSjkTGYmyT4PsZ1Xb7R_Z_hPtb8mGQTROB-Mq9PZuNNb-G8iMZQI-X13Ae7qQ-JpfwjX7BbzzysQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754564436</pqid></control><display><type>article</type><title>Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Stein, Moshe E. ; Kuten, Abraham ; Drumea, Keren ; Moshkowitz, Boaz ; Nativ, Ofer ; Munichor, Mariane ; Haim, Nissim</creator><creatorcontrib>Stein, Moshe E. ; Kuten, Abraham ; Drumea, Keren ; Moshkowitz, Boaz ; Nativ, Ofer ; Munichor, Mariane ; Haim, Nissim</creatorcontrib><description>Background
The efficacy of cisplatinum combined chemotherapy modalities was investigated in a variety of trials for patients with advanced seminoma. Results regarding remission rates and survival are encouraging.
Methods
Between December 1981 and January 1994, 13 patients with either relapsed (followng radiotherapy failure) or primarily advanced seminoma were treated with cisplatin‐based chemotherapy at the Northern Israel Oncology Center.
Results
Eleven (84%) patients achieved complete clearance of all sites of disease. One patient demonstrated clinically and radiographically remarkable shrinkage of an abdominal mass, and laparotomy revealed fibrotic/necrotic tissue without viable tumor cells. After a mean follow‐up of 58 months (range 4–168), 12 patients (92%) are alive and well without evidence of malignancy. One patient, in whom a 2‐cm abdominal mass is stable radiographically, is under observation with no sign of tumor activity. Side effects were tolerable; no patient developed chemotherapy‐induced sepsis. One patient developed spontaneous pneumothorax a few days after completion of his first chemotherapy cycle, which resolved with treatment.
Conclusions
Our results confirm the efficacy and safety of cisplatin‐based chemotherapy in the treatment of advanced seminoma, even in pre‐irradiated patients. J. Surg. Oncol. 64:331–335, 1997. © 1997 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/(SICI)1096-9098(199704)64:4<331::AID-JSO15>3.0.CO;2-5</identifier><identifier>PMID: 9142192</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; advanced seminoma ; Aged ; Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bleomycin - administration & dosage ; Chemotherapy ; Cisplatin - administration & dosage ; cisplatin-based chemotherapy ; Etoposide - administration & dosage ; high response rate ; Humans ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Remission Induction ; Seminoma - drug therapy ; Seminoma - secondary ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - pathology ; Tropical medicine ; Vinblastine - administration & dosage</subject><ispartof>Journal of surgical oncology, 1997-04, Vol.64 (4), p.331-335</ispartof><rights>Copyright © 1997 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4625-ec316ef098f102225066555c74a92fb655cf345f4a13d1f7494d996cf9e594943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2668571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9142192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stein, Moshe E.</creatorcontrib><creatorcontrib>Kuten, Abraham</creatorcontrib><creatorcontrib>Drumea, Keren</creatorcontrib><creatorcontrib>Moshkowitz, Boaz</creatorcontrib><creatorcontrib>Nativ, Ofer</creatorcontrib><creatorcontrib>Munichor, Mariane</creatorcontrib><creatorcontrib>Haim, Nissim</creatorcontrib><title>Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
The efficacy of cisplatinum combined chemotherapy modalities was investigated in a variety of trials for patients with advanced seminoma. Results regarding remission rates and survival are encouraging.
Methods
Between December 1981 and January 1994, 13 patients with either relapsed (followng radiotherapy failure) or primarily advanced seminoma were treated with cisplatin‐based chemotherapy at the Northern Israel Oncology Center.
Results
Eleven (84%) patients achieved complete clearance of all sites of disease. One patient demonstrated clinically and radiographically remarkable shrinkage of an abdominal mass, and laparotomy revealed fibrotic/necrotic tissue without viable tumor cells. After a mean follow‐up of 58 months (range 4–168), 12 patients (92%) are alive and well without evidence of malignancy. One patient, in whom a 2‐cm abdominal mass is stable radiographically, is under observation with no sign of tumor activity. Side effects were tolerable; no patient developed chemotherapy‐induced sepsis. One patient developed spontaneous pneumothorax a few days after completion of his first chemotherapy cycle, which resolved with treatment.
Conclusions
Our results confirm the efficacy and safety of cisplatin‐based chemotherapy in the treatment of advanced seminoma, even in pre‐irradiated patients. J. Surg. Oncol. 64:331–335, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>advanced seminoma</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bleomycin - administration & dosage</subject><subject>Chemotherapy</subject><subject>Cisplatin - administration & dosage</subject><subject>cisplatin-based chemotherapy</subject><subject>Etoposide - administration & dosage</subject><subject>high response rate</subject><subject>Humans</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Remission Induction</subject><subject>Seminoma - drug therapy</subject><subject>Seminoma - secondary</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - pathology</subject><subject>Tropical medicine</subject><subject>Vinblastine - administration & dosage</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvEzEUhUcIVELhJyB5gaBdTPB74tAiVUNpB4VOpfJYXjmOTQfmEewJNP8eh4lmA4KV7XuPj87RlySnBE8JxvTl0U2RF8cEK5kqrGZHRKkM82PJ5_yEMTKfnxVv0nc3JRGv2RRP8_IVTcW9ZDL-uJ9Mog9Neabww-RRCF8xxkpJfpAcKMIpUXSSdHkV1rXuqzZd6mBXyNzaputvrdfrLapapFc_dGviItimartGz9H53dr6ysYp6hyKWnTV-d2XFhXBa1ujsjVd3X3Zoty2vfVzRNSMpLEBf5w8cLoO9sn-PEw-vj3_kF-mi_KiyM8WqeGSitQaRqR1sYUjsQMVWEohhMm4VtQt4904xoXjmrAVcRlXfBWrGaesUPHBDpPng-_ad983NvTQVMHYutat7TYBspnKiGQ4Cl_8Wyi4kJwzycaoxncheOtg7atG-y0QDDtkADtksAMAOwAwIAPJgUNEBhCRwW9kwABDXgIFEX2f7hNslo1dja57RnH_bL_Xweja-cijCqOMSjkTGYmyT4PsZ1Xb7R_Z_hPtb8mGQTROB-Mq9PZuNNb-G8iMZQI-X13Ae7qQ-JpfwjX7BbzzysQ</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Stein, Moshe E.</creator><creator>Kuten, Abraham</creator><creator>Drumea, Keren</creator><creator>Moshkowitz, Boaz</creator><creator>Nativ, Ofer</creator><creator>Munichor, Mariane</creator><creator>Haim, Nissim</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>199704</creationdate><title>Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994</title><author>Stein, Moshe E. ; Kuten, Abraham ; Drumea, Keren ; Moshkowitz, Boaz ; Nativ, Ofer ; Munichor, Mariane ; Haim, Nissim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4625-ec316ef098f102225066555c74a92fb655cf345f4a13d1f7494d996cf9e594943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>advanced seminoma</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bleomycin - administration & dosage</topic><topic>Chemotherapy</topic><topic>Cisplatin - administration & dosage</topic><topic>cisplatin-based chemotherapy</topic><topic>Etoposide - administration & dosage</topic><topic>high response rate</topic><topic>Humans</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Remission Induction</topic><topic>Seminoma - drug therapy</topic><topic>Seminoma - secondary</topic><topic>Testicular Neoplasms - drug therapy</topic><topic>Testicular Neoplasms - pathology</topic><topic>Tropical medicine</topic><topic>Vinblastine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stein, Moshe E.</creatorcontrib><creatorcontrib>Kuten, Abraham</creatorcontrib><creatorcontrib>Drumea, Keren</creatorcontrib><creatorcontrib>Moshkowitz, Boaz</creatorcontrib><creatorcontrib>Nativ, Ofer</creatorcontrib><creatorcontrib>Munichor, Mariane</creatorcontrib><creatorcontrib>Haim, Nissim</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stein, Moshe E.</au><au>Kuten, Abraham</au><au>Drumea, Keren</au><au>Moshkowitz, Boaz</au><au>Nativ, Ofer</au><au>Munichor, Mariane</au><au>Haim, Nissim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1997-04</date><risdate>1997</risdate><volume>64</volume><issue>4</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Background
The efficacy of cisplatinum combined chemotherapy modalities was investigated in a variety of trials for patients with advanced seminoma. Results regarding remission rates and survival are encouraging.
Methods
Between December 1981 and January 1994, 13 patients with either relapsed (followng radiotherapy failure) or primarily advanced seminoma were treated with cisplatin‐based chemotherapy at the Northern Israel Oncology Center.
Results
Eleven (84%) patients achieved complete clearance of all sites of disease. One patient demonstrated clinically and radiographically remarkable shrinkage of an abdominal mass, and laparotomy revealed fibrotic/necrotic tissue without viable tumor cells. After a mean follow‐up of 58 months (range 4–168), 12 patients (92%) are alive and well without evidence of malignancy. One patient, in whom a 2‐cm abdominal mass is stable radiographically, is under observation with no sign of tumor activity. Side effects were tolerable; no patient developed chemotherapy‐induced sepsis. One patient developed spontaneous pneumothorax a few days after completion of his first chemotherapy cycle, which resolved with treatment.
Conclusions
Our results confirm the efficacy and safety of cisplatin‐based chemotherapy in the treatment of advanced seminoma, even in pre‐irradiated patients. J. Surg. Oncol. 64:331–335, 1997. © 1997 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9142192</pmid><doi>10.1002/(SICI)1096-9098(199704)64:4<331::AID-JSO15>3.0.CO;2-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 1997-04, Vol.64 (4), p.331-335 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult advanced seminoma Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bleomycin - administration & dosage Chemotherapy Cisplatin - administration & dosage cisplatin-based chemotherapy Etoposide - administration & dosage high response rate Humans Liver Neoplasms - secondary Lymphatic Metastasis Male Medical sciences Middle Aged Pharmacology. Drug treatments Remission Induction Seminoma - drug therapy Seminoma - secondary Testicular Neoplasms - drug therapy Testicular Neoplasms - pathology Tropical medicine Vinblastine - administration & dosage |
| title | Cisplatin-based chemotherapy in advanced seminoma: Experience of the Northern Israel Oncology Center: 1981-1994 |
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