Iodine-123 labelled radiopharmaceuticals and single-photon emission tomography: a natural liaison

Most nuclear medicine departments possess one or more imaging apparatuses for single-photon emission tomography (SPET). Molecules of biological interest to assess metabolism and receptor function are often labelled with 123I, which allows proper SPET imaging. The various methods for radiolabelling a...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1997-03, Vol.24 (3), p.331-344
Main Authors: BOURGUIGNON, M. H, PAUWELS, E. K. J, LOC'H, C, MAZIERE, B
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - diagnostic imaging
Contrast media. Radiopharmaceuticals
Heart - diagnostic imaging
Humans
Iodine Radioisotopes
Isotope Labeling
Medical sciences
Neoplasms - diagnostic imaging
Pharmacology. Drug treatments
Radioimmunodetection
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon
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Summary:Most nuclear medicine departments possess one or more imaging apparatuses for single-photon emission tomography (SPET). Molecules of biological interest to assess metabolism and receptor function are often labelled with 123I, which allows proper SPET imaging. The various methods for radiolabelling are reviewed. As the biological integrity of these agents has been demonstrated for numerous radiopharmaceuticals, the purpose of this review is to summarize the efficacy in various fields of medicine, including the imaging of tumours, infection, myocardium and cerebrum.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF01728774