Does Digoxin Provide Additional Hemodynamic and Autonomic Benefit at Higher Doses in Patients With Mild to Moderate Heart Failure and Normal Sinus Rhythm?

Objectives. This study sought to examine the hemodynamic and autonomic dose response to digoxin. Background. Previous studies have demonstrated an increase in contractility and heart rate variability with digitalis preparations. However, little is known about the dose-response to digoxin, which has...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 1997-05, Vol.29 (6), p.1206-1213
Main Authors: Slatton, Monte L, Irani, Waleed N, Hall, Shelley A, Marcoux, Lucille G, Page, Richard L, Grayburn, Paul A, Eichhorn, Eric J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiotonic agents
Cardiotonic Agents - administration & dosage
Cardiotonic Agents - therapeutic use
Cardiovascular system
Digoxin - administration & dosage
Digoxin - therapeutic use
Dose-Response Relationship, Drug
Echocardiography
Electrocardiography, Ambulatory
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Male
Medical sciences
Middle Aged
Norepinephrine - blood
Pharmacology. Drug treatments
Ventricular Function, Left - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives. This study sought to examine the hemodynamic and autonomic dose response to digoxin. Background. Previous studies have demonstrated an increase in contractility and heart rate variability with digitalis preparations. However, little is known about the dose-response to digoxin, which has a narrow therapeutic window. Methods. Nineteen patients with moderate heart failure and a left ventricular ejection fraction
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(97)00057-0