A randomized prospective study of antibiotic prophylaxis during abdominal surgery

The safety and efficacy of intravenous cefmetazole for prophylaxis before abdominal operations were compared with those of intravenous cefoxitin in a randomized, prospective clinical study. Eighty-nine evaluable patients were enrolled. These patients underwent primarily clean/contaminated (56%) and...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1989, Vol.23 (suppl-D), p.79-83
Main Authors: Gaskill, Harold V., Levine, Barry A.
Format: Article
Language:English
Subjects:
Abdomen - surgery
Adolescent
Adult
Aged
Cefmetazole - therapeutic use
Cefoxitin - therapeutic use
Female
Humans
Male
Middle Aged
Premedication
Prospective Studies
Random Allocation
Surgical Wound Infection - microbiology
Surgical Wound Infection - prevention & control
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Summary:The safety and efficacy of intravenous cefmetazole for prophylaxis before abdominal operations were compared with those of intravenous cefoxitin in a randomized, prospective clinical study. Eighty-nine evaluable patients were enrolled. These patients underwent primarily clean/contaminated (56%) and contaminated (39%) operations. A total of three (3%) patients developed postoperative wound infections. Two patients (2%) developed non-life-threatening adverse drug reactions. There were no life-threatening adverse drug reactions. There were no significant differences between the cefmetazole and cefoxitin study groups. Cefmetazole appears to be as safe and as efficacious as cefoxitin antibiotic in prophylaxis for intra-abdominal operations.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/23.suppl_D.79