Cerebral metastases in childhood malignancies

Between January 1982 to June 1994, 154 children with non-CNS malignant tumours excluding leukaemias and lymphomas were admitted and treated at the UKMC. Symptomatic (10 cases; 6.5%) and non-symptomatic (2 cases; 1.2%) cranial metastases (calvarial, dural and/or parenchymal) were seen in 12 (7.8%) ca...

Full description

Saved in:
Bibliographic Details
Published in:Acta neurochirurgica 1997-01, Vol.139 (3), p.182-187
Main Authors: Tasdemiroglu, E, Patchell, R A
Format: Article
Language:English
Subjects:
Adolescent
Age
Brain
Brain Neoplasms - diagnosis
Brain Neoplasms - mortality
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Cerebellum
Chemotherapy
Child
Child, Preschool
Children
Combined Modality Therapy
Craniotomy
Female
Follow-Up Studies
Humans
Infant
Leukemia
Lymphoma
Magnetic Resonance Imaging
Male
Malignancy
Metastases
Neurosurgery
Pediatrics
Prognosis
Radiation therapy
Radiotherapy
Skull
Surgery
Survival
Survival Rate
Tomography, X-Ray Computed
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Between January 1982 to June 1994, 154 children with non-CNS malignant tumours excluding leukaemias and lymphomas were admitted and treated at the UKMC. Symptomatic (10 cases; 6.5%) and non-symptomatic (2 cases; 1.2%) cranial metastases (calvarial, dural and/or parenchymal) were seen in 12 (7.8%) cases. Among these 12 cases, 7 had intracranial parenchymal metastases (4.5%). Three cases had multiple intracranial parenchymal metastases. Only one case had infratentorial (cerebellar) metastasis. The patients' ages ranged from 1 to 18 years (mean age was 7.3 years). The male:female ratio was 5:2. While six patients' brain metastases diagnosed during subsequent relapses, one patient first presented with brain metastasis. Time elapsed between the diagnosis of the primary disease and intracranial metastasis ranged from 0 to 755 days (mean 327 days). Histopathological diagnoses were confirmed in 4 cases who had craniotomy and tumour removal. Mean survival following the diagnosis of intracranial lesion was 157 days (ranged from 0 to 412 days). Despite the aggressive treatment, including surgery, chemotherapy and radiotherapy, 6 cases died with progression or relapse of the intracranial disease. In conclusion, the incidence of paediatric intracranial parenchymal metastasis is 4.5%. Prognosis is poor and intracranial disease is the primary cause of death.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01844748