TISSUE VARIATION OF ACUTE HAEMODYNAMIC CHANGES BY NG-NITRO-L-ARGININE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE AND WISTAR-KYOTO RATS

SUMMARY 1. The acute effects of nitric oxide synthase inhibition on the haemodynamics in stroke‐prone spontaneously hypertensive (SHRSP) and normotensive Wistar‐Kyoto (WKY) rats were investigated using radiolabeled microspheres. 2. Intravenous administration of 3 and 6 mg/kg NG‐nitro‐L ‐arginine (l....

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Bibliographic Details
Published in:Clinical and experimental pharmacology & physiology 1997-04, Vol.24 (3-4), p.249-255
Main Authors: Higashino, H., Simeonova, K., Lambev, I., Suzuki, A.
Format: Article
Language:English
Subjects:
Animals
brain
Enzyme Inhibitors - pharmacology
Hemodynamics - drug effects
Hemodynamics - physiology
Hypertension - physiopathology
inhibitors
microspheres
NG-nitro-L-arginine
nitric oxide
Nitric Oxide - physiology
Nitric Oxide Synthase - antagonists & inhibitors
Nitroarginine - pharmacology
Organ Specificity
Rats
Rats, Inbred SHR
Rats, Inbred WKY
regional blood flow
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
stroke-prone spontaneously hypertensive rats
Vasodilation - physiology
Wistar-Kyoto rats
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Summary:SUMMARY 1. The acute effects of nitric oxide synthase inhibition on the haemodynamics in stroke‐prone spontaneously hypertensive (SHRSP) and normotensive Wistar‐Kyoto (WKY) rats were investigated using radiolabeled microspheres. 2. Intravenous administration of 3 and 6 mg/kg NG‐nitro‐L ‐arginine (l.‐NNA) caused a significant increase in total peripheral resistance, a decrease in cardiac output and an increase in blood pressure in both SHRSP and WKY rats. 3. Significant decreases in regional blood flow (RBF) in the lung, muscle and stomach of WKY rats were observed following L‐NNA administration. 4. NG‐nitro‐L ‐arginine produced a 70% increase in brain regional blood flow at a dose of 6 mg/kg only in SHRSP. 5. There was a variation in the involvement of nitric oxide (NO) in different tissues. 6. It is concluded that hypertension in SHRSP augments NO‐mediated vasodilation.
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.1997.tb01815.x