The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide

We have characterized multiple transcripts from the band 3 gene expressed in rat and mouse kidney. In each species, the major transcript lacks sequence from the first three exons of the band 3 gene. The murine transcript predicts a kidney band 3 polypeptide with a truncated amino terminus, lacking t...

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Bibliographic Details
Published in:The Journal of biological chemistry 1989-05, Vol.264 (14), p.7784-7787
Main Authors: Brosius, F C, Alper, S L, Garcia, A M, Lodish, H F
Format: Article
Language:English
Subjects:
Animals
Anion Exchange Protein 1, Erythrocyte - genetics
Base Sequence
Biological and medical sciences
Biotechnology
DNA Probes
DNA Restriction Enzymes
Endonucleases
Erythrocytes - analysis
Exons
Female
Fundamental and applied biological sciences. Psychology
genes
Genetic engineering
Genetic technics
Introns
kidney
Kidney - analysis
Male
Methods. Procedures. Technologies
Mice
Molecular and cellular biology
Molecular cloning
Molecular genetics
Nucleic Acid Hybridization
Oocytes - metabolism
Rats
Rats, Inbred Strains
RNA, Messenger - genetics
Single-Strand Specific DNA and RNA Endonucleases
Transcription, Genetic
Transcription. Transcription factor. Splicing. Rna processing
Xenopus laevis
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Summary:We have characterized multiple transcripts from the band 3 gene expressed in rat and mouse kidney. In each species, the major transcript lacks sequence from the first three exons of the band 3 gene. The murine transcript predicts a kidney band 3 polypeptide with a truncated amino terminus, lacking the first 79 amino acids of erythroid band 3. When expressed in Xenopus oocytes this truncated band 3 functions in anion transport.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)83108-8