Chromatin remodeling and transcription

Recent advances highlight two important chromatin remodeling systems involved in the trancriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other i...

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Bibliographic Details
Published in:Current opinion in genetics & development 1997-04, Vol.7 (2), p.182-191
Main Authors: Tsukiyama, Toshio, Wu, Carl
Format: Article
Language:English
Subjects:
Acetylation
Acetyltransferases
Adenosine Triphosphate
Animals
Cell Cycle Proteins - metabolism
Chromatin
DNA - chemistry
DNA Helicases
DNA-Binding Proteins - metabolism
Fungal Proteins - metabolism
Histone Acetyltransferases
Histone Deacetylases - metabolism
Histones
Humans
Nuclear Proteins - metabolism
Nucleic Acid Conformation
Nucleosomes
p300-CBP Transcription Factors
Protein Kinases - metabolism
Saccharomyces cerevisiae Proteins
TATA-Binding Protein Associated Factors
Tetrahymena
Transcription Factor TFIID
Transcription Factors - metabolism
Transcription, Genetic
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Summary:Recent advances highlight two important chromatin remodeling systems involved in the trancriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acetylation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(97)80127-X