Ejaculation‐retarding properties of paroxetine in patients with primary premature ejaculation: a double‐blind, randomized, dose‐response study

Objective  To compare the influence of a daily dose of 20 or 40 mg of the serotonergic antidepressant drug paroxetine in delaying ejaculation in patients with primary premature ejaculation. Patients and methods  Thirty‐four patients with primary premature ejaculation were randomly assigned to receiv...

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Bibliographic Details
Published in:British Journal of Urology 1997-04, Vol.79 (4), p.592-595
Main Authors: WALDINGER, M.D., HENGEVELD, M.W., ZWINDERMAN, A.H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antidepressive Agents, Second-Generation - therapeutic use
Anxiety - drug therapy
Biological and medical sciences
Dose-Response Relationship, Drug
Double-Blind Method
Ejaculation - drug effects
Genital system. Reproduction
Humans
Male
Medical sciences
Middle Aged
paroxetine
Paroxetine - therapeutic use
Pharmacology. Drug treatments
Premature ejaculation
serotonin
Serotonin Uptake Inhibitors - therapeutic use
sexual disorder
Sexual Dysfunction, Physiological - drug therapy
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Summary:Objective  To compare the influence of a daily dose of 20 or 40 mg of the serotonergic antidepressant drug paroxetine in delaying ejaculation in patients with primary premature ejaculation. Patients and methods  Thirty‐four patients with primary premature ejaculation were randomly assigned to receive 20 mg or 40 mg daily of paroxetine for 7 weeks in a double‐blind fixed‐dose trial after an initial dose of 20 mg/day in the first week. Patients and their female partners were interviewed separately. In the group receiving 20 mg, one of two capsules consisted of placebo and in the group receiving 40 mg, both capsules contained active drug. Results  The trial was completed by 27 men; both groups showed a statistically significant difference from the baseline values of ejaculation latency (P
ISSN:0007-1331
1464-410X
DOI:10.1046/j.1464-410X.1997.00102.x