Mice Selected for Low and High Blood Magnesium Levels: A New Model for Stress Studies

HENROTTE, J. G., G. FRANCK, M. SANTARROMANA, H. FRANCES, D. MOUTON AND R. MOTTA. Mice selected for low and high blood magnesium levels: A new model for stress studies. PHYSIOL BEHAV 61(5)653–658, 1997.—Extra- and intracellular magnesium levels have previously been shown to be genetically controlled...

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Published in:Physiology & behavior 1997-05, Vol.61 (5), p.653-658
Main Authors: Henrotte, Jean G, Franck, Gisèle, Santarromana, Monique, Francès, Henriette, Mouton, Denise, Motta, Roland
Format: Article
Language:English
Subjects:
Aggression - physiology
Animals
Arousal - genetics
Arousal - physiology
Behavior
Behavioral psychophysiology
Biological and medical sciences
Brain - physiology
Brain weight
Erythrocytes - metabolism
Female
Fundamental and applied biological sciences. Psychology
Genetics
Magnesium
Magnesium - blood
Male
Methods
Mice
Mice, Inbred Strains
Monoamines
Norepinephrine - physiology
Organ Size - genetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Selection, Genetic
Species Specificity
Stress
Tissue Distribution
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Summary:HENROTTE, J. G., G. FRANCK, M. SANTARROMANA, H. FRANCES, D. MOUTON AND R. MOTTA. Mice selected for low and high blood magnesium levels: A new model for stress studies. PHYSIOL BEHAV 61(5)653–658, 1997.—Extra- and intracellular magnesium levels have previously been shown to be genetically controlled in humans and in the mouse. To further study this genetic regulation, mice were selected from a heterogeneous population, for low (MGL mice) and high (MGH mice) red blood cell (RBC) magnesium values. These values diverged rapidly in the two strains, to reach a stable difference between the 14th and 18th generations. MGL mice also exhibited significantly lower plasma, kidney, and skull bone magnesium contents and higher urinary magnesium excretion and total brain weights. Moreover, in stressful conditions, MGL mice displayed a more aggressive behavior that the control MGH strain. Altogether, MGL mice showed a more restless behavior, a higher rectal temperature, and much higher brain (+17%) and urine (+200%) noradrenaline levels than the MGH animals. These strains, thus, constitute a new animal model for the study of magnesium metabolism and its relationships with catecholamines, stress sensitivity, and aggressive behavior.
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(96)00506-9