Dual Effects on Gastric Acid Secretion of Electrical Stimulation of Anterior Parts of the Rat Hypothalamus

The effect of electrical stimulation of anterior parts of the hypothalamus on gastric acid secretion was examined in rats anesthetized with urethane. Electrical stimulation (0.5 mA, 2 msec, 10 Hz, for 10 min) of the lateral hypothalamic area (LHA) induced a marked increase in basal gastric acid outp...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.49(1), pp.37-42
Main Authors: OKUMA, Yasunobu, OSUMI, Yoshitsugu
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Gastric Acid - metabolism
Hypothalamus, Anterior - physiology
Male
Rats
Rats, Inbred Strains
Stomach
Vagotomy
Vagus Nerve - physiology
Vertebrates: digestive system
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Summary:The effect of electrical stimulation of anterior parts of the hypothalamus on gastric acid secretion was examined in rats anesthetized with urethane. Electrical stimulation (0.5 mA, 2 msec, 10 Hz, for 10 min) of the lateral hypothalamic area (LHA) induced a marked increase in basal gastric acid output. Electrical stimulation of the preoptic area (PO), the paraventricular nucleus (PVN) and the anterior hypothalamus (AH) also induced increases in basal acid secretion. Electrical stimulation of the PO, PVN and AH inhibited the increase in acid secretion induced by electrical stimulation of the vagus nerve (1 mA, 0.5 msec, 3 Hz). These inhibitory effects were abolished by bilateral cutting of the splanchnic nerves. On the other hand, the stimulation of the LHA had no effects on vagally stimulated gastric acid secretion. Electrical stimulation of the anterior parts of the hypothalamus induces dual effects, vagally mediated increases in basal gastric acid output and splanchnic mediated inhibition of the vagally stimulated gastric acid output.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.49.37