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Dual Effects on Gastric Acid Secretion of Electrical Stimulation of Anterior Parts of the Rat Hypothalamus

The effect of electrical stimulation of anterior parts of the hypothalamus on gastric acid secretion was examined in rats anesthetized with urethane. Electrical stimulation (0.5 mA, 2 msec, 10 Hz, for 10 min) of the lateral hypothalamic area (LHA) induced a marked increase in basal gastric acid outp...

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Published in:	Japanese Journal of Pharmacology 1989, Vol.49(1), pp.37-42
Main Authors:	OKUMA, Yasunobu, OSUMI, Yoshitsugu
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences Blood Pressure Electric Stimulation Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism Hypothalamus, Anterior - physiology Male Rats Rats, Inbred Strains Stomach Vagotomy Vagus Nerve - physiology Vertebrates: digestive system
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container_title	Japanese Journal of Pharmacology
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creator	OKUMA, Yasunobu OSUMI, Yoshitsugu
description	The effect of electrical stimulation of anterior parts of the hypothalamus on gastric acid secretion was examined in rats anesthetized with urethane. Electrical stimulation (0.5 mA, 2 msec, 10 Hz, for 10 min) of the lateral hypothalamic area (LHA) induced a marked increase in basal gastric acid output. Electrical stimulation of the preoptic area (PO), the paraventricular nucleus (PVN) and the anterior hypothalamus (AH) also induced increases in basal acid secretion. Electrical stimulation of the PO, PVN and AH inhibited the increase in acid secretion induced by electrical stimulation of the vagus nerve (1 mA, 0.5 msec, 3 Hz). These inhibitory effects were abolished by bilateral cutting of the splanchnic nerves. On the other hand, the stimulation of the LHA had no effects on vagally stimulated gastric acid secretion. Electrical stimulation of the anterior parts of the hypothalamus induces dual effects, vagally mediated increases in basal gastric acid output and splanchnic mediated inhibition of the vagally stimulated gastric acid output.
doi_str_mv	10.1254/jjp.49.37
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Electrical stimulation of the anterior parts of the hypothalamus induces dual effects, vagally mediated increases in basal gastric acid output and splanchnic mediated inhibition of the vagally stimulated gastric acid output.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.49.37</identifier><identifier>PMID: 2724681</identifier><identifier>CODEN: JJPAAZ</identifier><language>eng</language><publisher>Kyoto: The Japanese Pharmacological Society</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure ; Electric Stimulation ; Fundamental and applied biological sciences. 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Electrical stimulation of the anterior parts of the hypothalamus induces dual effects, vagally mediated increases in basal gastric acid output and splanchnic mediated inhibition of the vagally stimulated gastric acid output.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Gastric Acid - metabolism</topic><topic>Hypothalamus, Anterior - physiology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach</topic><topic>Vagotomy</topic><topic>Vagus Nerve - physiology</topic><topic>Vertebrates: digestive system</topic><toplevel>online_resources</toplevel><creatorcontrib>OKUMA, Yasunobu</creatorcontrib><creatorcontrib>OSUMI, Yoshitsugu</creatorcontrib><creatorcontrib>Department of Pharmacology</creatorcontrib><creatorcontrib>Kochi Medical School</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKUMA, Yasunobu</au><au>OSUMI, Yoshitsugu</au><aucorp>Department of Pharmacology</aucorp><aucorp>Kochi Medical School</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual Effects on Gastric Acid Secretion of Electrical Stimulation of Anterior Parts of the Rat Hypothalamus</atitle><jtitle>Japanese Journal of Pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1989</date><risdate>1989</risdate><volume>49</volume><issue>1</issue><spage>37</spage><epage>42</epage><pages>37-42</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><coden>JJPAAZ</coden><abstract>The effect of electrical stimulation of anterior parts of the hypothalamus on gastric acid secretion was examined in rats anesthetized with urethane. 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source	Elsevier ScienceDirect Journals
subjects	Animals Biological and medical sciences Blood Pressure Electric Stimulation Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism Hypothalamus, Anterior - physiology Male Rats Rats, Inbred Strains Stomach Vagotomy Vagus Nerve - physiology Vertebrates: digestive system
title	Dual Effects on Gastric Acid Secretion of Electrical Stimulation of Anterior Parts of the Rat Hypothalamus
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