Systemic and regional hemodynamic effects of gallopamil in patients with essential hypertension

Systemic and regional hemodynamics were assessed in 10 patients with uncomplicated mild to moderate essential hypertension before and during gallopamil therapy. Cardiac output was measured in triplicate with indocyanine dye. Plasma volume and renal blood flow were measured radioisotopically. Immedia...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 1997-03, Vol.11 (1), p.39-42
Main Authors: KETELHUT, R. G, MESSERLI, F. H, LOSEM, C, FROHLICH, E. D, MICHALEWICZ, L
Format: Article
Language:English
Subjects:
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Calcium Channel Blockers - administration & dosage
Calcium Channel Blockers - therapeutic use
Cardiovascular system
Delayed-Action Preparations
Exercise
Female
Gallopamil - administration & dosage
Gallopamil - therapeutic use
Hemodynamics - drug effects
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Neurotransmitter Agents - blood
Pharmacology. Drug treatments
Plasma Volume - drug effects
Regional Blood Flow - drug effects
Vascular Resistance - drug effects
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Summary:Systemic and regional hemodynamics were assessed in 10 patients with uncomplicated mild to moderate essential hypertension before and during gallopamil therapy. Cardiac output was measured in triplicate with indocyanine dye. Plasma volume and renal blood flow were measured radioisotopically. Immediately following the initial dose of a slow-release (SR) formulation of gallopamil, a significant fall in arterial pressure associated with a decreased total peripheral resistance and a reflex increase in heart rate and cardiac output were seen. Then, after 8-12 weeks of treatment, arterial pressure and total peripheral resistance remained reduced, but heart rate and cardiac output returned to pretreatment levels. Gallopamil also produced significant reductions in renal and splanchnic vascular resistance. Plasma volume and total blood volume did not change. Thus, gallopamil reduced arterial pressure and vascular resistances without fluid retention or prolonged reflexive changes.
ISSN:0920-3206
1573-7241
DOI:10.1023/A:1007743705737