Lithium enhances synaptic transmission in neonatal rat hippocampus

The effects of lithium on excitatory synaptic transmission were studied in the CA1 region of hippocampal slices taken from 14- to 30-day-old rats using extracellular recording techniques. Lithium (2–18 mM) reversibly increased the field excitatory postsynaptic potentials in a concentration-dependent...

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Bibliographic Details
Published in:Neuroscience 1997-05, Vol.78 (2), p.385-391
Main Authors: Valentı́n, A, Garcı́a-Seoane, J.J, Colino, A
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - physiology
Axons - drug effects
Axons - physiology
Biological and medical sciences
CA1 region
Evoked Potentials - drug effects
excitability
excitatory postsynaptic potential
hippocampus
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
lithium
Lithium - pharmacology
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
rat
Rats
Rats, Wistar
Receptors, Presynaptic - drug effects
Stimulation, Chemical
Synaptic Transmission - drug effects
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Summary:The effects of lithium on excitatory synaptic transmission were studied in the CA1 region of hippocampal slices taken from 14- to 30-day-old rats using extracellular recording techniques. Lithium (2–18 mM) reversibly increased the field excitatory postsynaptic potentials in a concentration-dependent manner. Application of lithium for 6–15 min had no effect on the synaptic input–output function, while application of lithium for 20–35 min shifted this curve to the left. Lithium reversibly increased the amplitude of the presynaptic fibre volley in a concentration- and calcium-dependent manner. Lithium decreased paired-pulse facilitation measured at 50-ms interstimulus intervals. The results indicate that lithium enhances excitatory synaptic transmission in CA1 pyramidal cells by at least two different actions.
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(96)00618-5