Transcriptional activation functions in BRCA2

The BRCA2 gene encodes a large protein of unknown function and is found mutated in 45% of familial breast cancers. Here we show that the portion of BRCA2 encoded by its third exon shares homology with a known transcription factor and is capable of activating transcription, indicating a potential fun...

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Bibliographic Details
Published in:Nature (London) 1997-04, Vol.386 (6627), p.772-773
Main Authors: Milner, Jonathan, Ponder, Bruce, Hughes-Davies, Luke, Seltmann, Matthias, Kouzarides, Tony
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
BRCA2 Protein
Breast cancer
Breast Neoplasms - genetics
Cell Line
Exons
Humanities and Social Sciences
Humans
Molecular Sequence Data
multidisciplinary
Neoplasm Proteins - chemistry
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Proto-Oncogene Proteins c-jun - chemistry
Science
Science (multidisciplinary)
scientific-correspondence
Sequence Homology, Amino Acid
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - physiology
Transcriptional Activation
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Summary:The BRCA2 gene encodes a large protein of unknown function and is found mutated in 45% of familial breast cancers. Here we show that the portion of BRCA2 encoded by its third exon shares homology with a known transcription factor and is capable of activating transcription, indicating a potential function of BRCA2.
ISSN:0028-0836
1476-4687
DOI:10.1038/386772a0