Nonlinear distribution of atenolol between plasma and cerebrospinal fluid

Long Evans rats were given atenolol doses ranging from 0.27 to 5.4 mg/kg by intraperitoneal injection Animals were dosed once every 2 hr for a total of five doses. Atenolol concentrations 1 hr after the last dose were measured from simultaneously obtained plasma and cerebrospinal fluid (CSF) samples...

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Bibliographic Details
Published in:Pharmaceutical research 1989-03, Vol.6 (3), p.248-251
Main Authors: GENGO, F. M, FAGAN, S. C, HOPKINS, L. N, WAGNER, D, SCHUSTER, D. P
Format: Article
Language:English
Subjects:
Animals
Atenolol - blood
Atenolol - cerebrospinal fluid
Atenolol - pharmacokinetics
Biological and medical sciences
Brain - metabolism
Brain Ischemia - blood
Brain Ischemia - cerebrospinal fluid
Catecholaminergic system
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Rats
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Summary:Long Evans rats were given atenolol doses ranging from 0.27 to 5.4 mg/kg by intraperitoneal injection Animals were dosed once every 2 hr for a total of five doses. Atenolol concentrations 1 hr after the last dose were measured from simultaneously obtained plasma and cerebrospinal fluid (CSF) samples CSF concentrations of atenolol were not proportional to plasma concentrations. The ratio of CSF/plasma concentrations was higher (0.33) at lower plasma atenolol levels (less than 100 ng/ml) than at the higher atenolol plasma levels (0.05) (P less than 0.001). The relationship between plasma and cerebrospinal fluid atenolol concentrations was best described by the sum of a Michaelis-Menten and linear function. Animals were also given atenolol doses and then subjected to global cerebral ischemia. The relationship of atenolol concentrations from plasma and CSF in these animals was linear, with a constant partition ratio of 0.02. Together these data show that atenolol partitioning between plasma and CSF is nonlinear and possibly an energy-dependent process.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1015973719096