Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells

Cytotoxic cells specific for Toxoplasma gondii-infected cells were detected in the peripheral blood leukocytes from a patient with acute toxoplasmosis. The cytotoxicity was mediated by CD5+, CD4-, CD8+ cells. The cytotoxic T cells lysed Toxoplasma-infected target cells with HLA class I restriction....

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Bibliographic Details
Published in:The Journal of parasitology 1989-06, Vol.75 (3), p.411-416
Main Authors: Yano, Akihiko, Aosai, Fumie, Ohta, Masaho, Hasekura, Hayato, Sugane, Kazuo, Hayashi, Shigeo
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigen-Presenting Cells - immunology
antigene
antigenos
Antigens
Antigens, Differentiation, T-Lymphocyte - immunology
Antigens, Protozoan - immunology
B lymphocytes
Cell membranes
Cultured cells
Cytotoxicity, Immunologic
Histocompatibility Antigens Class I - immunology
HLA antigens
HLA-DR Antigens - immunology
Humans
immunite
immunity
Immunology
inmunidad
linfocitos
lymphocyte
lymphocytes
Molecules
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes, Cytotoxic - immunology
toxicidad
toxicite
toxicity
toxoplasma
Toxoplasma - immunology
toxoplasmose
Toxoplasmosis
Toxoplasmosis - immunology
Tumors
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Description
Summary:Cytotoxic cells specific for Toxoplasma gondii-infected cells were detected in the peripheral blood leukocytes from a patient with acute toxoplasmosis. The cytotoxicity was mediated by CD5+, CD4-, CD8+ cells. The cytotoxic T cells lysed Toxoplasma-infected target cells with HLA class I restriction. Two types of T cell clones were established from peripheral blood leukocytes of a patient with chronic toxoplasmosis; one was a CD5+, CD4-, CD8+ cytotoxic cell specific for Toxoplasma-infected cells, and the other was a CD5+, CD4+, CD8- proliferative cell that responded to Toxoplasma antigen. Toxoplasma-infected cell-specific cytotoxic cloned T cells recognize the infected target cells in the context of the HLA class I molecules, and the CD8 molecule was involved in the cytotoxicity. Toxoplasma antigen-specific proliferative cloned T cells were stimulated by Toxoplasma antigen-pulsed or Toxoplasma-infected cells in conjunction with HLA-DR molecule on the target cells. Thus, antigen presentation by Toxoplasma-infected cells for activation of both cytotoxic and proliferative T cells has been demonstrated.
ISSN:0022-3395
1937-2345
DOI:10.2307/3282598