Seasonality and Malaria in a West African Village: Does High Parasite Density Predict Fever Incidence?

In this cohort study, the authors studied the effect of blood malaria parasite density on fever incidence in children in an endemic area with 9 days' follow-up of 1- to 12-year-old children during two time periods: the end of the dry season (May 1993: n = 783) and the end of the rainy season (O...

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Bibliographic Details
Published in:American journal of epidemiology 1997-05, Vol.145 (9), p.850-857
Main Authors: Bouvier, Paul, Rougemont, André, Breslow, Norman, Doumbo, Ogobara, Delley, Véronique, Dicko, Allassane, Diakite, Mahamadou, Mauris, Anne, Robert, Claude-François
Format: Article
Language:English
Subjects:
Africa, Western - epidemiology
Analysis. Health state
anemia
Animals
Anopheles - growth & development
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
epidemiologic factors
Epidemiology
Female
fever
Fever - epidemiology
General aspects
Human protozoal diseases
Humans
Incidence
Infant
Infectious diseases
Logistic Models
Malaria
Malaria - epidemiology
Male
Medical sciences
Multivariate Analysis
Parasitemia - epidemiology
Parasitic diseases
Plasmodium
Plasmodium falciparum - growth & development
Population
preventive medicine
Proportional Hazards Models
prospective studies
Protozoal diseases
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression Analysis
Seasons
splenomegaly
Statistics, Nonparametric
Tropical medicine
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Summary:In this cohort study, the authors studied the effect of blood malaria parasite density on fever incidence in children in an endemic area with 9 days' follow-up of 1- to 12-year-old children during two time periods: the end of the dry season (May 1993: n = 783) and the end of the rainy season (October 1993: n = 841) in Bougoula, West Africa (region of Sikasso, Mali). The cumulative incidence of fever (temperature >38.0°C) was 2.0% in the dry season and 8.2% in the rainy season (p < 0.0001). In the rainy season, the risk of fever was increased in children of ages 1–3 years (relative risk (RR) = 2.5, 95% confidence interval (Cl) 1.6–4.1); in those with an initial parasitemia >15, 000/μl (RR = 2.7, 95% Cl 1.4–5.4); in children with an enlarged spleen (RR = 2.0, 95% Cl 1.2–3.3); or in those with anemia (hematocrit
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a009179