Sprouting in the hippocampus is layer-specific

Partial removal of layer-specific afferents of the hippocampus is said to induce sprouting of intact fibers from neighboring layers that invade the zone of the degenerating axons. However, recent in vivo and in vitro studies using sensitive anterograde tracers have failed to demonstrate sprouting ac...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 1997-05, Vol.20 (5), p.218-223
Main Authors: Frotscher, Michael, Heimrich, Bernd, Deller, Thomas
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain
Development. Senescence. Regeneration. Transplantation
Entorhinal Cortex - physiology
Fundamental and applied biological sciences. Psychology
Hippocampus - physiology
Humans
Medical research
Nerve Fibers - physiology
Neurology
Neuronal Plasticity
Vertebrates: nervous system and sense organs
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Summary:Partial removal of layer-specific afferents of the hippocampus is said to induce sprouting of intact fibers from neighboring layers that invade the zone of the degenerating axons. However, recent in vivo and in vitro studies using sensitive anterograde tracers have failed to demonstrate sprouting across laminar boundaries. Sprouting does occur; but, it mainly involves unlesioned fiber systems terminating within the layer of fiber degeneration in addition to the degenerating afferents. These findings point to rigid laminar cues attracting certain fiber systems while repelling others in normal development and after partial deafferentation.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(96)01018-1