Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type

In the cerebrospinal fluid (CSF) of 53 patients with senile dementia of the Alzheimer type (SDAT) and 12 elderly controls, we measured somatostatin (SLI) and its molecular forms high-molecular weight form (HMV-SST) somatostatin-25/28 (SST28/25), and des-ala-somatostatin (des-ala-SST) using high pres...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1997-06, Vol.41 (11), p.1124-1130
Main Authors: Strittmatter, M., Cramer, H., Reuner, C., Strubel, D., Hamann, G., Schimrigk, K.
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - drug therapy
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Chlorpromazine - administration & dosage
Chlorpromazine - pharmacology
Chlorpromazine - therapeutic use
Chromatography, High Pressure Liquid
Cognition Disorders - diagnosis
Cross Reactions
CSF
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
dementia
Female
Humans
Male
Medical sciences
Molecular Weight
Neurology
SDAT
somatostatin
Somatostatin - biosynthesis
Somatostatin - cerebrospinal fluid
somatostatin-14
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Summary:In the cerebrospinal fluid (CSF) of 53 patients with senile dementia of the Alzheimer type (SDAT) and 12 elderly controls, we measured somatostatin (SLI) and its molecular forms high-molecular weight form (HMV-SST) somatostatin-25/28 (SST28/25), and des-ala-somatostatin (des-ala-SST) using high pressure liquid chromatography (HPLC) and a radioimmunoassay. In SDAT, SLI was significantly decreased ( p < 0.05) and correlated with dementia scores ( r = −0.65, p < 0.05). HPLC separation showed a marked heterogeneity of SLI in the CSF with a preponderance of SST-14 and SST-25/28. The significant loss of SST-14 ( p < 0.05) in SDAT was found to be correlated with dementia scores ( r = 0.65). Moreover, qualitative and quantitative changes in the molecular pattern of SLI in SDAT indicated dysregulated synthesis and/or processing of somatostatin relating to the severity of dementia. The long-term administration of neuroleptics in severe cases of SDAT caused a significant increase of SLI ( p < 0.05) and influenced the ratio of HMV-SST/SST-14 and SST25/28/SST-14.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(96)00211-9