Thyrotropin-releasing hormone and central nervous system trauma

TRH and TRH analogues improve physiological function, survival, and neurological outcome in a variety of models of CNS trauma, including impact spinal cord injury in cats and rats, fluid-percussion-induced brain injury in rats, and compression-induced brain injury in cats. The mechanism by which TRH...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1989, Vol.553 (1 Thyrotropin-R), p.380-384
Main Authors: Faden, A I, Vink, R, McIntosh, T K
Format: Article
Language:English
Subjects:
Animals
Brain Injuries - physiopathology
Disease Models, Animal
Spinal Cord Injuries - physiopathology
Thyrotropin-Releasing Hormone - pharmacology
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Summary:TRH and TRH analogues improve physiological function, survival, and neurological outcome in a variety of models of CNS trauma, including impact spinal cord injury in cats and rats, fluid-percussion-induced brain injury in rats, and compression-induced brain injury in cats. The mechanism by which TRH improves such functions may relate to its ability to improve blood flow and metabolism in the region of injury. Beneficial effects on blood flow may possibly relate to antagonism of the physiological effects of endogenous opioids, leukotrienes, or platelet-activating factor.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1989.tb46659.x