Convenient Oxidation of Phenothiazine Salts to Their Sulfoxides with Aqueous Nitrous Acid

A Simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1989-04, Vol.78 (4), p.334-336
Main Authors: Owens, Margart L., Juenge, Eric C., Poklis, Alphonse
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical Phenomena
Chemistry
Medical sciences
Neuropharmacology
Nitrous Acid
Oxidation-Reduction
Pharmacology. Drug treatments
Phenothiazines - analysis
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Spectrophotometry, Ultraviolet
Stereoisomerism
Sulfoxides - chemical synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A Simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600780415