A NEW ANTITUMOR ANTIBIOTIC, FR900840: I. DISCOVERY, IDENTIFICATION, ISOLATION AND CHARACTERIZATION

A new antitumor antibiotic, FR900840, was isolated from a culture broth of Streptomyces strain No. 8727 as a pale yellowish prism and the molecular formula was determined to be C7H11N3O5. The antibiotic exhibited prominent antitumor effects on human tumor cell lines both in vitro and in vivo.

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Bibliographic Details
Published in:Journal of antibiotics 1989/04/25, Vol.42(4), pp.542-548
Main Authors: NISHIMURA, MAKOTO, NAKADA, HIROHISA, NAKAJIMA, HIDENORI, HORI, YASUHIRO, EZAKI, MASAMI, GOTO, TOSHIO, OKUHARA, MASAKUNI
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Animals
antibiotic FR900840
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, Antineoplastic - therapeutic use
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
antitumor antibiotics
Applied microbiology
Biological and medical sciences
Breast Neoplasms - drug therapy
Chemotherapic agents
Female
Fermentation
Fundamental and applied biological sciences. Psychology
Humans
Hydroxybutyrates - biosynthesis
Hydroxybutyrates - isolation & purification
Hydroxybutyrates - pharmacology
Hydroxybutyrates - therapeutic use
Leukemia P388 - drug therapy
Lung Neoplasms - drug therapy
Mice
Microbiology
Microscopy, Electron
Serine - analogs & derivatives
Serine - biosynthesis
Serine - isolation & purification
Serine - pharmacology
Serine - therapeutic use
Spores, Bacterial - ultrastructure
Streptomyces - classification
Streptomyces - growth & development
Streptomyces - metabolism
Streptomyces - ultrastructure
Temperature
tumor cell lines
Tumor Cells, Cultured
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Description
Summary:A new antitumor antibiotic, FR900840, was isolated from a culture broth of Streptomyces strain No. 8727 as a pale yellowish prism and the molecular formula was determined to be C7H11N3O5. The antibiotic exhibited prominent antitumor effects on human tumor cell lines both in vitro and in vivo.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.542