Kinetics of Aluminum in Rats I: Dose-Dependent Elimination from Blood after Intravenous Administration

• Published in: Journal of pharmaceutical sciences 1989-03, Vol.78 (3), p.200-202
• Main Authors: Pai, Sudhakar M., Melethil, Srikumaran
• Format: Article
• Language: English
• Subjects: Aluminum - administration & dosage; Aluminum - blood; Aluminum - pharmacokinetics; Animals; Biological and medical sciences; General and cellular metabolism. Vitamins; Half-Life; Injections, Intravenous; Male; Medical sciences; Pharmacology. Drug treatments; Rats; Rats, Inbred Strains
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600780305

Aluminum (Al) kinetics after intravenous bolus administration were studied in the rat. The animals received either 0.1 or 1.0 mg/kg (n = 6 at each dose) of elemental Al as the sulfate salt. The Al content of serial blood samples was determined by flameless atomic absorption spectrophotometry. Blood and plasma Al–time profiles after both doses were monoexponential in most cases. Increasing the administered dose increased the elimination half-life (mean ± SD) from 1.20 ± 0.25 to 2.41 ± 0.26h. A corresponding decrease in systemic clearance was observed (49.6 ± 11.0 to 18.4 ± 4.6 mL/kg.h). Both changes were significant (p < 0.05). Significant differences were also observed in the volume of distribution, the values of which were 78.3 ± 17.2 and 58.9 ± 8.5 mL/kg at the low and high doses, respectively. At both doses, blood:plasma ratios ranged from 0.8 to 1.0, indicating considerable uptake/binding of the element by blood cells.