Cytoprotective Effect of Plasmin Inhibitor on Necrotizing Agent-Induced Gastric Lesions in Rats

We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential dif...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.50(1), pp.72-74
Main Authors: MURAKAMI, Motonobu, YOO, Jung Keun, TERAMURA, Sanae, INADA, Masami, SAITA, Hiroshi, MATSUO, Keiji, KUSAKA, Sigeru, KITA, Toru, MIYAKE, Takeo
Format: Article
Language:English
Subjects:
Aminocaproic Acid - pharmacology
Ammonia - pharmacology
Animals
Biological and medical sciences
Cell Survival - drug effects
Digestive system
Ethanol - pharmacology
Fibrinolysin - antagonists & inhibitors
Gastric Mucosa - cytology
Gastric Mucosa - drug effects
Indomethacin - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Tranexamic Acid - pharmacology
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Summary:We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential difference induced by 50% ethanol and 1 % ammonia. The protection of gastric mucosa afforded by tranexamic acid and aminocaproic acid was not affected by pretreatment with indomethacin (5 mg/kg). These results suggest that plasmin inhibitor plays an important role in the prevention of gastric deep necrosis following exposure of the stomach to a damaging agent.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.50.72