Polypoidal rhinosinusitis in cystic fibrosis: a clinical and histopathological study

• Published in: Clinical otolaryngology and allied sciences 1997-04, Vol.22 (2), p.167-171
• Main Authors: ROWE-JONES, J.M., SHEMBEKAR, M., TRENDELL-SMITH, N., MACKAY, I.S.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Cell Count; computerized tomography; cystic fibrosis; Cystic Fibrosis - complications; Endoscopy; eosinophils; Eosinophils - pathology; Female; Humans; Leukocyte Count; Linear Models; Lymphocyte Count; Macrophages - pathology; Male; Nasal Polyps - complications; Nasal Polyps - diagnostic imaging; Nasal Polyps - pathology; Nasal Polyps - surgery; neutrophils; Neutrophils - pathology; Paranasal Sinus Neoplasms - complications; Paranasal Sinus Neoplasms - diagnostic imaging; Paranasal Sinus Neoplasms - pathology; Paranasal Sinus Neoplasms - surgery; Plasma Cells - pathology; polyposis; Polyps - complications; Polyps - diagnostic imaging; Polyps - pathology; Polyps - surgery; Prospective Studies; Recurrence; Rhinitis - complications; Rhinitis - diagnostic imaging; Rhinitis - pathology; Rhinitis - surgery; rhinosinusitis; Sinusitis - complications; Sinusitis - diagnostic imaging; Sinusitis - pathology; Sinusitis - surgery; Tomography, X-Ray Computed
• ISSN: 0307-7772; 1365-2273
• DOI: 10.1046/j.1365-2273.1997.00003.x

The eosinophil may play a key role in the pathogenesis of nasal polyposis. Polyps in cystic fibrosis, however, have been described as neutrophilic. We compared the cell counts in polyps from 44 patients with cystic fibrosis to polyps from 50 patients without cystic fibrosis. The clinical profile, CT‐scan and time to polyp recurrence were also compared with the cell counts in the patients with cystic fibrosis. No significant difference was detected in the number of patients with eosinophils (P > 0.25). Significantly more patients in the group with cystic fibrosis had polyp neutrophils (P