Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis

Psoriasis is a common chronic inflammatory disorder of the skin. To further understand the pathogenesis of psoriasis we have chosen to investigate the molecular genetic basis of the disorder. We have used a two-stage approach to search the human genome for the location of genes conferring susceptibi...

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Bibliographic Details
Published in:Human molecular genetics 1997-05, Vol.6 (5), p.813-820
Main Authors: Trembath, Richard C., Lee Clough, R., Rosbotham, Jane L., Jones, Andrew B., Camp, Richard D. R., Frodsham, Angela, Browne, Julie, Barber, Ruth, Terwilliger, Joseph, Mark Lathrop, G., Barker, Jonathan N. W. N.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes, Human, Pair 6
Dermatology
Genetic Linkage
Genetic Markers
Genome, Human
Humans
Major Histocompatibility Complex - genetics
Medical sciences
Pedigree
Psoriasis - genetics
Psoriasis. Parapsoriasis. Lichen
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Summary:Psoriasis is a common chronic inflammatory disorder of the skin. To further understand the pathogenesis of psoriasis we have chosen to investigate the molecular genetic basis of the disorder. We have used a two-stage approach to search the human genome for the location of genes conferring susceptibility to psoriasis, using a total of 106 affected sibling pairs identified from 68 independent families. As over a third of the extended kindreds included affected relatives besides siblings, in addition to an analysis of allele sharing between affected sibling pairs, a novel linkage strategy was applied that extracts full non-parametric information. Four principal regions of possible linkage were identified on chromosomes 2, 8, 20 (p
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/6.5.813