Effect of Sustained-Release Verapamil on the Morning Systemic Arterial Pressure Surge During Daily Activity in Patients With Systemic Hypertension

In a placebo-controlled study of 13 subjects with systemic hypertension, sustained-release verapamil reduced the morning surge in systolic pressure by 10.2 mm Hg (p = 0.04), diastolic pressure by 11.1 mm Hg (p = 0.008), and heart rate by 3.3 beats/min (p = 0.17). Blunting of the morning hemodynamic...

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Bibliographic Details
Published in:The American journal of cardiology 1997-05, Vol.79 (9), p.1252-1255
Main Authors: Rosito, MD, Guido A, Gebara, MD, Otavio C.E, McKenna, RN, Carol A, Solomon, MD, Harold S, Muller, MD, James E, Tofler, MD, Geoffrey H
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antihypertensive agents
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular system
Circadian Rhythm - drug effects
Delayed-Action Preparations
Double-Blind Method
Drug Administration Schedule
Drug therapy
Female
Fourier Analysis
Heart Rate - drug effects
Humans
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Monitoring, Physiologic
Pharmacology. Drug treatments
Verapamil - administration & dosage
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Summary:In a placebo-controlled study of 13 subjects with systemic hypertension, sustained-release verapamil reduced the morning surge in systolic pressure by 10.2 mm Hg (p = 0.04), diastolic pressure by 11.1 mm Hg (p = 0.008), and heart rate by 3.3 beats/min (p = 0.17). Blunting of the morning hemodynamic surge may be a mechanism by which verapamil could reduce the risk of plaque disruption and acute coronary events in the morning.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00093-3