N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated...

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Bibliographic Details
Published in:Experimental brain research 1997-04, Vol.114 (2), p.271-278
Main Authors: SCHROEDER, C. E, JAVITT, D. C, STEINSCHNEIDER, M, MEHTA, A. D, GIVRE, S. J, VAUGHAN, H. G, AREZZO, J. C
Format: Article
Language:English
Subjects:
Animals
Bicuculline - administration & dosage
Bicuculline - analogs & derivatives
Bicuculline - pharmacology
Biological and medical sciences
Central nervous system
Dizocilpine Maleate - administration & dosage
Dizocilpine Maleate - pharmacology
Electrophysiology
Evoked Potentials, Visual - drug effects
Evoked Potentials, Visual - physiology
Fundamental and applied biological sciences. Psychology
Macaca fascicularis
Male
Microinjections
N-Methylaspartate - physiology
Receptors, GABA-A - physiology
Receptors, N-Methyl-D-Aspartate - physiology
Time Factors
Vertebrates: nervous system and sense organs
Visual Cortex - drug effects
Visual Cortex - physiology
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Summary:In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.
ISSN:0014-4819
1432-1106
DOI:10.1007/PL00005635