EFFECT OF KETANSERIN ON SODIUM NITROPRUSSIDE REQUIREMENTS, ARTERIAL PRESSURE CONTROL AND HEART RATE FOLLOWING CORONARY ARTERY BYPASS SURGERY

In a double-blind, placebo controlled study ketanserin, a serotonin S2 antagonist, was administered to hypertensive patients who had undergone coronary artery bypass surgery. Patients were allocated randomly to receive placebo or ketanserin at an infusion rate of 0.05, 1 or 2 mg kg−1 h−1. Sodium nit...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1989-05, Vol.62 (5), p.527-531
Main Authors: HODSMAN, NADIA B.A., COLVIN, JOHN R., KENNY, GAVIN N.C.
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Pressure - drug effects
Coronary Artery Bypass
Double-Blind Method
Female
Ferricyanides - therapeutic use
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Hypertension - drug therapy
Hypertension - etiology
Hypertension - physiopathology
Ketanserin - therapeutic use
Male
Medical sciences
Middle Aged
Nitroprusside - therapeutic use
Postoperative Complications
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Summary:In a double-blind, placebo controlled study ketanserin, a serotonin S2 antagonist, was administered to hypertensive patients who had undergone coronary artery bypass surgery. Patients were allocated randomly to receive placebo or ketanserin at an infusion rate of 0.05, 1 or 2 mg kg−1 h−1. Sodium nitroprusside was used as escape medication. Ketanserin reduced the nitroprusside requirements and improved the quality of arterial pressure control in all groups, and this was significant in the low- and high-dose groups. There was a significant decrease in heart rate in the low- and high-dose groups compared with placebo, and no effect in patients who received the medium dose of ketanserin. Ketanserin may be a useful treatment for hypertension following coronary artery surgery as it reduced arterial pressure without reflex tachycardia.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/62.5.527