Isometric Handgrip Exercise Increases Endothelin-1 Plasma Levels in Patients With Chronic Congestive Heart Failure

This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily phys...

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Bibliographic Details
Published in:The American journal of cardiology 1997-05, Vol.79 (9), p.1261-1263
Main Authors: Mangieri, MD, Enrico, Tanzilli, MD, Gaetano, Barillà, MD, Francesco, Ciavolella, MD, PhD, Massimo, Serafini, MD, Gianluca, Nardi, MD, Marcello, Mangiaracina, MD, Francesco, Scibilia, MD, Giovanni, Dell'Italia, MD, Louis J., Campa, MD, Pietro P.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Cardiology. Vascular system
Chronic Disease
Endothelin-1 - blood
Exercise
Exercise - physiology
Hand Strength - physiology
Heart
Heart failure
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics - physiology
Humans
Male
Medical sciences
Middle Aged
Plasma
Space life sciences
Ventricular Function, Left - physiology
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Summary:This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily physical activity, thus contributing to progressive deterioration of left ventricular function.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00096-9