Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment

The genes for insulin-like growth factor 1 receptor (IGF1R), aggrecan (AGC1), β₂-microglobulin (B2M), and an H6-related gene have been mapped to a single chicken microchromo-some by genetic linkage analysis. In addition, a second H6-related gene was mapped to chicken macrochromosome 3. The Igf1r and...

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Bibliographic Details
Published in:Mammalian genome 1997-06, Vol.8 (6), p.436-440
Main Authors: Jones, C T, Morrice, D R, Paton, I R, Burt, D W
Format: Article
Language:English
Subjects:
Aggrecan
Aggrecans
Animals
b2-microglobulin
Base Sequence
beta 2-Microglobulin - genetics
Biological Evolution
Breeding
Chickens - genetics
Chromosome 15
Chromosome Mapping
Chromosomes, Human, Pair 15
Conserved Sequence
Crosses, Genetic
Extracellular Matrix Proteins
Female
Gene mapping
Genes
Genetic analysis
Genetic Predisposition to Disease
Genomes
Homeodomain Proteins - genetics
Humans
Insulin
Lectins, C-Type
Linkage analysis
Male
Mice
Polymorphism, Genetic
Proteoglycans - genetics
Receptors, Somatomedin - genetics
Sequence Homology, Nucleic Acid
Synteny
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Summary:The genes for insulin-like growth factor 1 receptor (IGF1R), aggrecan (AGC1), β₂-microglobulin (B2M), and an H6-related gene have been mapped to a single chicken microchromo-some by genetic linkage analysis. In addition, a second H6-related gene was mapped to chicken macrochromosome 3. The Igf1r and Agc1 loci are syntenic on mouse Chr 7, together with Hmx3, an H6-like locus. This suggests that the H6-related locus, which maps to the chicken microchromosome in this study, is the homolog of mouse Hmx3. The IGF1R, AGC1, and B2M loci are located on human Chr 15, probably in the same order as found for this chicken microchromosome. This conserved segment, however, is not entirely conserved in the mouse and is split between Chr 7 (Igf1r-Age) and 2 (B2m). This comparison also predicts that the HMX3 locus may map to the short arm of human Chr 15. The conserved segment defined by the IGF1R-AGC1-HMX3—B2M loci is approximately 21–35 Mb in length and probably covers the entire chicken microchromosome. These results suggest that a segment of human Chr 15 has been conserved as a chicken micro-chromosome. The significance of this result is discussed with reference to the evolution of the avian and mammalian genomes.
ISSN:0938-8990
1432-1777
DOI:10.1007/s003359900463