Pharmacokinetics of Zileuton and Its Metabolites in Patients with Renal Impairment

The pharmacokinetics of zileuton and its conjugated metabolites were evaluated in patients with chronic renal impairment. Five healthy volunteers (creatinine clearance >90 mL/min), five patients with renal failure requiring hemodialysis, six with mild (creatinine clearance, 60–90 mL/min), eight w...

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Bibliographic Details
Published in:Journal of clinical pharmacology 1997-05, Vol.37 (5), p.395-404
Main Authors: Awni, Walid M., Wong, Shekman, Chu, Sou-yie, Patterson, Karen, Hansen, Robert, Machinist, Joseph M., Drajesk, Jeff, Keane, William F., Halstenson, Charles E.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Female
Humans
Hydroxyurea - administration & dosage
Hydroxyurea - analogs & derivatives
Hydroxyurea - pharmacokinetics
Kidney Diseases - metabolism
Kidney Diseases - physiopathology
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Kidney Function Tests
Lipoxygenase Inhibitors - administration & dosage
Lipoxygenase Inhibitors - pharmacokinetics
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Renal Dialysis
Respiratory system
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Summary:The pharmacokinetics of zileuton and its conjugated metabolites were evaluated in patients with chronic renal impairment. Five healthy volunteers (creatinine clearance >90 mL/min), five patients with renal failure requiring hemodialysis, six with mild (creatinine clearance, 60–90 mL/min), eight with moderate (creatinine clearance, 30–59 mL/min), and six with severe (creatinine clearance
ISSN:0091-2700
1552-4604
DOI:10.1002/j.1552-4604.1997.tb04317.x