Effects of vigabatrin on motor potentials evoked with magnetic stimulation

We studied the effect of an acute loading dose of vigabatrin on threshold of motor responses and duration of silent period elicited with cortical magnetic stimulation in normal subjects. In contrast to phenytoin, vigabatrin does not increase the motor threshold of first dorsal interosseus muscle. We...

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Bibliographic Details
Published in:Electroencephalography and clinical neurophysiology 1997-04, Vol.105 (2), p.124-127
Main Authors: Mavroudakis, Nicolas, Caroyer, Jean Marc, Brunko, Eric, de Beyl, Diederik Zegers
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Differential Threshold - drug effects
Diphantoin
Electromyography
Evoked Potentials, Motor - drug effects
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
Hand
Humans
Magnetic stimulation
Magnetics
Male
Medical sciences
Middle Aged
Muscles - physiology
Neuropharmacology
Pharmacology. Drug treatments
Phenytoin - pharmacology
Physical Stimulation
Silent period
Vigabatrin
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Summary:We studied the effect of an acute loading dose of vigabatrin on threshold of motor responses and duration of silent period elicited with cortical magnetic stimulation in normal subjects. In contrast to phenytoin, vigabatrin does not increase the motor threshold of first dorsal interosseus muscle. We also show that, although vigabatrin increases GABA concentrations in the central nervous system, duration of silent period studied at various stimulus intensities is not modified after vigabatrin administration.
ISSN:0924-980X
0013-4694
1872-7093
DOI:10.1016/S0924-980X(96)96607-2